ArticleSocial cognitive and affective neuroscience2014
Me, myself and I: temporal dysfunctions during self-evaluation in patients with schizophrenia.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Narrative identity in the psychosis spectrum: A systematic review and developmental model.Clinical psychology review · 2021Pooled it
- A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia.Frontiers in neurology · 2019Pooled it
- Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.Schizophrenia bulletin · 2017Pooled it
- We like to move it - patients with schizophrenia spectrum disorders are impaired in estimating their physical fitness levels and benefit from individualized exercise.European archives of psychiatry and clinical neuroscience · 2025Trial
- Mirroring minds: assessing the relative stability of self-appraisal and reflected appraisal in daily life.Frontiers in psychology · 2025Article
- Functional connectome fingerprint of holistic-analytic cultural style.Social cognitive and affective neuroscience · 2022Article
- Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia.Psychiatry investigation · 2021Article
- Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis.Frontiers in psychiatry · 2021Article
- Neural Correlates of Mentalizing in Individuals With Clinical High Risk for Schizophrenia: ALE Meta-Analysis.Frontiers in psychiatry · 2021Review
- Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.Human brain mapping · 2019Article
- Exploring Sex Differences in the Neural Correlates of Self-and Other-Referential Gender Stereotyping.Frontiers in behavioral neuroscience · 2019Article
- Pain empathy in schizophrenia: an fMRI study.Social cognitive and affective neuroscience · 2016Article
- Aberrant Salience Is Related to Dysfunctional Self-Referential Processing in Psychosis.Schizophrenia bulletin · 2016Article
- Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study.Psychiatry research · 2015Article
- Neurobiology of insight deficits in schizophrenia: An fMRI study.Schizophrenia research · 2015Article
- Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study.PloS one · 2015Article
- Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia.NeuroImage. Clinical · 2015Article
- Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-concept is deeply affected in schizophrenia. Positive symptoms in particular are related to disturbed self/other distinctions. The neural networks underlying self-evaluation in schizophrenia have barely been investigated. The study reported here involved 13 patients with schizophrenia and 13 matched controls. During functional MRI, participants decided in three conditions whether the presented positive and negative personality traits characterized themselves, an intimate person, or included a certain letter. Based on the responses, each experimental condition was designed using a flexible factorial model. Controls and patients showed a similar behavioral pattern during self-evaluation, with group comparison revealing decreased activation in patients in the left inferior temporal gyrus and both temporal poles during self-ascription of traits, and in the anterior medial prefrontal cortex during evaluation of an intimate person. In patients, positive symptoms correlated positively with brain activation in the left parahippocampus during trait self-ascription. Hence, while evaluating themselves, schizophrenia patients revealed decreased activation in areas related to self-awareness overlapping with networks involved in theory of mind, empathy and social knowledge. Moreover, patients' brain activation during self-reflection was affected by the current positive symptomatology. The close interaction between self and other highlights the clinical and social relevance of self-processing deficits in schizophrenia.
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