ArticleBiological psychiatry2014
Local gyrification index in probands with psychotic disorders and their first-degree relatives.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies.Brain imaging and behavior · 2022Pooled it
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Longitudinal Trajectories of Cortical Folding in Schizophrenia Spectrum Disorders: A 13-Year Follow-Up Study.Schizophrenia bulletin · 2026Article
- Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis.Translational psychiatry · 2025Article
- Psychiatric Antecedents in Adolescents at Clinical High Risk for Psychosis: Insights from the "Parma At-Risk Mental States" Follow-up Program.Research on child and adolescent psychopathology · 2025Article
- Obstetric complications, cortical gyrification, and cognition in first-episode psychosis.Psychological medicine · 2025Article
- Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia.Developmental cognitive neuroscience · 2025Article
- Cortical Gyrification and Cognitive Decline in the Human Brain With Type 2 Diabetes Mellitus.Brain and behavior · 2025Article
- Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study.Schizophrenia research · 2024Article
- Neural Correlates of Trait Impulsivity among Adult Healthy Individuals.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- A multiscale characterization of cortical shape asymmetries in early psychosis.Brain communications · 2024Article
- The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023Review
- Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.Annals of clinical and translational neurology · 2023Article
- Decreased cortical gyrification and surface area in the left medial parietal cortex in patients with treatment-resistant and ultratreatment-resistant schizophrenia.Psychiatry and clinical neurosciences · 2023Article
- Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting.Schizophrenia (Heidelberg, Germany) · 2022Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cognitive dysfunction and cortical structural abnormalities in first-episode drug-naïve schizophrenia patients with auditory verbal hallucination.Frontiers in psychiatry · 2022Article
- Hypogyrification in Generalized Anxiety Disorder and Associated with Insomnia Symptoms.Nature and science of sleep · 2022Article
- Structural Covariance of Cortical Gyrification at Illness Onset in Treatment Resistance: A Longitudinal Study of First-Episode Psychoses.Schizophrenia bulletin · 2021Article
- Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading.NPJ schizophrenia · 2021Article
Corrections and comments
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- Erratum issued
Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundPsychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype.
methodsRegional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for schizophrenia, SZA, and bipolar disorder. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values.
resultsProbands exhibited significant hypogyria compared with control subjects in three brain regions and relatives with Axis II cluster A disorders showed nearly significant hypogyria in these same regions. Local gyrification index values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant hypogyria were most widespread in SZA.
conclusionsPsychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.
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