ArticleGenomics2014
Comparison of assembled Clostridium botulinum A1 genomes revealed their evolutionary relationship.
Article in Genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A supervised Bayesian method for time (re)annotation of transcriptomics data.NAR genomics and bioinformatics · 2025Article
- Opportunistic Features of Non-Pathogens (Basel, Switzerland) · 2024Review
- Review
- How Botulinum Neurotoxin Light Chain A1 Maintains Stable Association with the Intracellular Neuronal Plasma Membrane.Toxins · 2022Article
- Identification of foodborne pathogenic bacteria using confocal Raman microspectroscopy and chemometrics.Frontiers in microbiology · 2022Article
- Therapeutic efficacy of new botulinum toxin identified in CCUG 7968 strain.Applied microbiology and biotechnology · 2021Article
- Comparative in silico genome analysis of Clostridium perfringens unravels stable phylogroups with different genome characteristics and pathogenic potential.Scientific reports · 2021Article
- Botulinum neurotoxin-encoding plasmids can be conjugatively transferred to diverse clostridial strains.Scientific reports · 2018Article
- An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production.PLoS computational biology · 2016Article
- Insights into the Origin of Clostridium botulinum Strains: Evolution of Distinct Restriction Endonuclease Sites in rrs (16S rRNA gene).Indian journal of microbiology · 2015Article
- Historical and current perspectives on Clostridium botulinum diversity.Research in microbiology · 2015Review
- Identification and characterization of a serious multidrug resistant Stenotrophomonas maltophilia strain in China.BioMed research international · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Clostridium botulinum encompasses bacteria that produce at least one of the seven serotypes of botulinum neurotoxin (BoNT/A-G). The availability of genome sequences of four closely related Type A1 or A1(B) strains, as well as the A1-specific microarray, allowed the analysis of their genomic organizations and evolutionary relationship. The four genomes share >90% core genes and >96% functional groups. Phylogenetic analysis based on COG shows closer relations of the A1(B) strain, NCTC 2916, to B1 and F1 than A1 strains. Alignment of the genomes of the three A1 strains revealed a highly similar chromosomal structure with three small gaps in the genome of ATCC 19397 and one additional gap in the genome of Hall A, suggesting ATCC 19379 as an evolutionary intermediate between Hall A and ATCC 3502. Analyses of the four gap regions indicated potential horizontal gene transfer and recombination events important for the evolution of A1 strains.
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