ArticleBioMed research international2013
Skin delivery of kojic acid-loaded nanotechnology-based drug delivery systems for the treatment of skin aging.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin.Drug delivery · 2021Trial
- Kojic Acid as a Natural Hypopigmenting Agent: Biological Activities, Delivery Challenges, and Nanotechnology-Based Strategies.Pharmaceutics · 2026Review
- The Therapeutic Promise of Kojic Acid: A Comprehensive Review.Mini reviews in medicinal chemistry · 2026Review
- 2,5-Dihydroxyphenylethanone: an anti-melanogenic bioactive compound isolated fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Dual Modulatory Effects of Phytochemicals fromMolecules (Basel, Switzerland) · 2025Article
- Tetrahydrocurcumin (THC) as a Melanogenesis Inhibitor in Melanoma Cell Lines.Biochemistry research international · 2025Article
- Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos.International journal of molecular sciences · 2024Article
- Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid.Pharmaceutics · 2023Article
- Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects andComputational and structural biotechnology journal · 2022Article
- Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety.International journal of molecular sciences · 2021Article
- Additive Effect of a Combination ofPharmaceuticals (Basel, Switzerland) · 2020Article
- Neural Stem Cells and Its Derivatives as a New Material for Melanin Inhibition.International journal of molecular sciences · 2017Review
- Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2017Review
- Improved production of kojic acid by mutagenesis of3 Biotech · 2017Article
- Skin Delivery and in Vitro Biological Evaluation of Trans-Resveratrol-Loaded Solid Lipid Nanoparticles for Skin Disorder Therapies.Molecules (Basel, Switzerland) · 2016Article
- A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis.International journal of nanomedicine · 2015Article
- Structural characterization and in vitro antioxidant activity of kojic dipalmitate loaded w/o/w multiple emulsions intended for skin disorders.BioMed research international · 2015Article
- Fermented broth in tyrosinase- and melanogenesis inhibition.Molecules (Basel, Switzerland) · 2014Review
- Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging.BioMed research international · 2014Article
- Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can modulate drug permeation through the skin and improve the drug activity. This study is aimed at structurally developing and characterizing a kojic acid-loaded LCS, consists of water (W), cetostearyl isononanoate (oil-O) and PPG-5-CETETH-20 (surfactant-S) and evaluating its in vitro skin permeation and retention. Three regions of the diagram were selected for characterization: A (35% O, 50% S, 15% W), B (30% O, 50% S, 20% W) and C (20% O, 50% S, 30% W), to which 2% KA was added. The formulations were subjected to polarized light microscopy, which indicated the presence of a hexagonal mesophase. Texture and bioadhesion assay showed that formulation B is suitable for topical application. According to the results from the in vitro permeation and retention of KA, the formulations developed can modulate the permeation of KA in the skin. The in vitro cytotoxic assays showed that KA-unloaded LCS and KA-loaded LCS didn't present cytotoxicity. PPG-5-CETETH-20-based systems may be a promising platform for KA skin delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.