ArticleBioMed research international2013
External mechanical microstimuli modulate the osseointegration of titanium implants in rat tibiae.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Enhanced Bone Remodeling Effects of Low-Modulus Ti-5Zr-3Sn-5Mo-25Nb Alloy Implanted in the Mandible of Beagle Dogs under Delayed Loading.ACS omega · 2019Article
- Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis.Journal of prosthodontic research · 2016Article
- Improved Bone Micro Architecture Healing Time after Implant Surgery in an Ovariectomized Rat.Journal of hard tissue biology · 2016Article
- Preclinical mouse models for assessing axial compression of long bones during exercise.BoneKEy reports · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effect of external mechanical microstimuli of controlled magnitude on the microarchitecture of the peri-implant bone beds in rat tibiae. MATERIALS AND
methodsTibiae of forty rats were fitted with two transcutaneous titanium cylinders. After healing, the implants were loaded to 1 to 3 N, five days/week for four weeks. These force levels translated into intraosseous strains of 700 ± 200 με, 1400 ± 400 με, and 2100 ± 600 με. After sacrifice, the implants' pullout strength was assessed. Second, the bone's microarchitecture was analyzed by microcomputed tomography (μCT) in three discrete regions of interest (ROIs). Third, the effect of loading on bone material properties was determined by nanoindentation.
resultsThe trabecular BV/TV significantly increased in an ROI of 0.98 mm away from the test implant in the 1 N versus the 3 N group with an opposite trend for cortical thickness. Pull-out strength significantly increased in the 2 N relatively to the nonstimulated group. Higher values of E-modulus and hardness were observed in the trabecular bone of the 2 N group.
conclusionThe in vivo mechanical loading of implants induces load-dependent modifications in bone microarchitecture and bone material properties in rat tibiae. In pull-out strength measurements, implant osseointegration was maximized at 2 N (1400 ± 400 με).
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