ArticleThe Journal of cell biology2013
Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 75 citations in OpenAlex.
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- Macrophages bend long fibres with flexural rigidity lower than 3 mN·nmParticle and fibre toxicology · 2026Article
- Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber-Induced Frustrated Phagocytosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
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- Gene dependence during mammalianMicrobial genomics · 2025Article
- Cranberry constituents prevent SOS-mediated filamentation of uropathogenicInfection and immunity · 2025Article
- Enhanced invasion and survival of antibiotic- resistantFrontiers in cellular and infection microbiology · 2025Article
- The role of bacterial size, shape and surface in macrophage engulfment of uropathogenic E. coli cells.PLoS pathogens · 2024Article
- [Construction and characterization of aNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.FEMS microbiology reviews · 2023Review
- Morphological transformations of vesicles with confined flexible filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Filamentous Bacteria as Targets to Study Phagocytosis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Plasmids Can Shift Bacterial Morphological Response against Antibiotic Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces.Soft matter · 2022Article
- Filamentous morphology of bacterial pathogens: regulatory factors and control strategies.Applied microbiology and biotechnology · 2022Review
- Engineering physical microenvironments to study innate immune cell biophysics.APL bioengineering · 2022Review
- Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes.The Journal of cell biology · 2021Article
- Characterisation ofJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Although filamentous morphology in bacteria has been associated with resistance to phagocytosis, our understanding of the cellular mechanisms behind this process is limited. To investigate this, we followed the phagocytosis of both viable and dead Legionella pneumophila filaments. The engulfment of these targets occurred gradually and along the longitudinal axis of the filament, therefore defining a long-lasting phagocytic cup stage that determined the outcome of phagocytosis. We found that these phagocytic cups fused with endosomes and lysosomes, events linked to the maturation of phagosomes according to the canonical pathway, and not with the remodeling of phagocytic cups. Nevertheless, despite acquiring phagolysosomal features these phagocytic cups failed to develop hydrolytic capacity before their sealing. This phenomenon hampered the microbicidal activity of the macrophage and enhanced the capacity of viable filamentous L. pneumophila to escape phagosomal killing in a length-dependent manner. Our results demonstrate that key aspects in phagocytic cup remodeling and phagosomal maturation could be influenced by target morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.