ArticleThe Plant cell2013
Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seeds.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
85 citing papers in PubMed, 137 citations in OpenAlex.
- Cadmium tolerance mediated by GhBCAT12 through branched-chain amino acid degradation via vacuolar sequestration in cotton.Stress biology · 2026Article
- Mitochondrial β-carbonic anhydrase is a conserved metabolic rheostat for branched-chain amino acid catabolism and metabolic flexibility.The New phytologist · 2026Article
- ZmTH1 Is Vital for Healthy Plant Growth and Promotes Cold/Drought Tolerance by Regulating Thiamin Diphosphate-Dependent Metabolisms in Maize.Plant biotechnology journal · 2026Article
- Breeding for colored quality protein popcorn with improved amino acid composition.Frontiers in plant science · 2026Article
- Opaque-2 induced zein reduction and lysine increase suggest a route to quality protein sweet corn.Frontiers in plant science · 2026Article
- Multi-omics dissection of COBMC plant biology · 2025Article
- Amino acids and BCAA composition of Mungbean (Vigna radiata L.) seeds and sprouts for plant-based protein applications.Scientific reports · 2025Article
- Loss-of-functional mutation in ANGUSTIFOLIA3 causes leucine hypersensitivity and hypoxia response during Arabidopsis thaliana seedling growth.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Network analysis combined with genome-wide association study helps identification of genes related to amino acid contents in soybean.BMC genomics · 2025Article
- 1-Aminocyclopropane-1-carboxylic acid induces resource reallocation inFrontiers in plant science · 2025Article
- Large scale deletion and rebalancing within theFrontiers in plant science · 2025Article
- Genome-wide association study of metabolic traits in the giant duckweed Spirodela polyrhiza.Plant biology (Stuttgart, Germany) · 2025Article
- Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases.Plant direct · 2024Article
- Article
- Editing the 19 kDa alpha-zein gene family generates non-opaque2-based quality protein maize.Plant biotechnology journal · 2024Article
- Chemical-tag-based semi-annotated metabolomics facilitates gene identification and specialized metabolic pathway elucidation in wheat.The Plant cell · 2024Article
- Proline, Cysteine and Branched-Chain Amino Acids in Abiotic Stress Response of Land Plants and Microalgae.Plants (Basel, Switzerland) · 2023Review
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- Genome-Wide Association Studies Using 3VmrMLM Model Provide New Insights into Branched-Chain Amino Acid Contents in Rice Grains.Plants (Basel, Switzerland) · 2023Article
- DROUGHT-INDUCED BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE enhances drought tolerance in rice.Plant physiology · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Branched-chain amino acids (BCAAs) are three of the nine essential amino acids in human and animal diets and are important for numerous processes in development and growth. However, seed BCAA levels in major crops are insufficient to meet dietary requirements, making genetic improvement for increased and balanced seed BCAAs an important nutritional target. Addressing this issue requires a better understanding of the genetics underlying seed BCAA content and composition. Here, a genome-wide association study and haplotype analysis for seed BCAA traits in Arabidopsis thaliana revealed a strong association with a chromosomal interval containing two branched-chain amino acid transferases, BCAT1 and BCAT2. Linkage analysis, reverse genetic approaches, and molecular complementation analysis demonstrated that allelic variation at BCAT2 is responsible for the natural variation of seed BCAAs in this interval. Complementation analysis of a bcat2 null mutant with two significantly different alleles from accessions Bayreuth-0 and Shahdara is consistent with BCAT2 contributing to natural variation in BCAA levels, glutamate recycling, and free amino acid homeostasis in seeds in an allele-dependent manner. The seed-specific phenotype of bcat2 null alleles, its strong transcription induction during late seed development, and its subcellular localization to the mitochondria are consistent with a unique, catabolic role for BCAT2 in BCAA metabolism in seeds.
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