ArticleThe Plant cell2013
Calcium/Calmodulin-dependent protein kinase is negatively and positively regulated by calcium, providing a mechanism for decoding calcium responses during symbiosis signaling.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 145 citations in OpenAlex.
- Symbiosis signalling genes negatively regulate root responses to salt stress via the CCaMK-IPD3 module in Medicago truncatula.Journal of experimental botany · 2026Article
- Abscisic acid at the crossroad of abiotic stress responses and plant-microbe interactions.PLoS pathogens · 2026Article
- Genotype-dependent stability and specialization of arbuscular mycorrhizal fungal communities under drought in common bean.Frontiers in plant science · 2026Article
- Untargeted metabolomics reveals novel metabolites in Lotus japonicus roots during arbuscular mycorrhiza symbiosis.The New phytologist · 2025Article
- Molecular and Systems Biology Approaches for Harnessing the Symbiotic Interaction in Mycorrhizal Symbiosis for Grain and Oil Crop Cultivation.International journal of molecular sciences · 2024Review
- Differential Responses ofPlants (Basel, Switzerland) · 2023Article
- Multitask Approach to Localize Rhizobial Type Three Secretion System Effector Proteins Inside Eukaryotic Cells.Plants (Basel, Switzerland) · 2023Article
- NIN-at the heart of NItrogen-fixing Nodule symbiosis.Frontiers in plant science · 2023Review
- Deciphering the role of SPL12 and AGL6 from a genetic module that functions in nodulation and root regeneration in Medicago sativa.Plant molecular biology · 2022Article
- Progress in the Self-Regulation System in Legume Nodule Development-AON (Autoregulation of Nodulation).International journal of molecular sciences · 2022Review
- Encoding, transmission, decoding, and specificity of calcium signals in plants.Journal of experimental botany · 2022Review
- Molecular Regulation of Arbuscular Mycorrhizal Symbiosis.International journal of molecular sciences · 2022Review
- Stress-associated developmental reprogramming in moss protonemata by synthetic activation of the common symbiosis pathway.iScience · 2022Article
- Calcium/calmodulin-mediated microbial symbiotic interactions in plants.Frontiers in plant science · 2022Review
- MtNF-YC6 and MtNF-YC11 are involved in regulating the transcriptional program of arbuscular mycorrhizal symbiosis.Frontiers in plant science · 2022Article
- Perception of lipo-chitooligosaccharides by the bioenergy cropPlant signaling & behavior · 2021Review
- Identification of differentially expressed genes associated with aluminum resistance in the soybean plant.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- A temperature-sensitive Mycobacterium smegmatis glgE mutation leads to a loss of GlgE enzyme activity and thermostability and the accumulation of α-maltose-1-phosphate.Biochimica et biophysica acta. General subjects · 2021Article
- Dephosphorylation of LjMPK6 by Phosphatase LjPP2C is Involved in Regulating Nodule Organogenesis inInternational journal of molecular sciences · 2020Article
- Design Principle for Decoding Calcium Signals to Generate Specific Gene Expression Via Transcription.Plant physiology · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The establishment of symbiotic associations in plants requires calcium oscillations that must be decoded to invoke downstream developmental programs. In animal systems, comparable calcium oscillations are decoded by calmodulin (CaM)-dependent protein kinases, but symbiotic signaling involves a calcium/CaM-dependent protein kinase (CCaMK) that is unique to plants. CCaMK differs from the animal CaM kinases by its dual ability to bind free calcium, via calcium binding EF-hand domains on the protein, or to bind calcium complexed with CaM, via a CaM binding domain. In this study, we dissect this dual regulation of CCaMK by calcium. We find that calcium binding to the EF-hand domains promotes autophosphorylation, which negatively regulates CCaMK by stabilizing the inactive state of the protein. By contrast, calcium-dependent CaM binding overrides the effects of autophosphorylation and activates the protein. The differential calcium binding affinities of the EF-hand domains compared with those of CaM suggest that CCaMK is maintained in the inactive state at basal calcium concentrations and is activated via CaM binding during calcium oscillations. This work provides a model for decoding calcium oscillations that uses differential calcium binding affinities to create a robust molecular switch that is responsive to calcium concentrations associated with both the basal state and with oscillations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.