ArticleeLife2013
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues.BMC genomics · 2025Article
- Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development.Developmental cell · 2025Article
- PRC2 promotes canalisation during endodermal differentiation.PLoS genetics · 2025Article
- Identification of the central intermediate in the extra-embryonic to embryonic endoderm transition through single-cell transcriptomics.Nature cell biology · 2022Article
- Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways.Nature communications · 2021Article
- The Organizer and Its Signaling in Embryonic Development.Journal of developmental biology · 2021Review
- Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds.Cells · 2021Article
- Article
- PI3K in stemness regulation: from development to cancer.Biochemical Society transactions · 2020Review
- Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition inMolecular cancer research : MCR · 2020Article
- Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas.PloS one · 2020Article
- Article
- GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation.Stem cell reports · 2018Article
- Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.Acta biomaterialia · 2016Article
- Extracellular matrix microarrays to study inductive signaling for endoderm specification.Acta biomaterialia · 2016Article
- Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.Developmental biology · 2015Article
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis.Developmental biology · 2014Article
- Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells.BMC biology · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
During embryonic development signalling pathways act repeatedly in different contexts to pattern the emerging germ layers. Understanding how these different responses are regulated is a central question for developmental biology. In this study, we used mouse embryonic stem cell (mESC) differentiation to uncover a new mechanism for PI3K signalling that is required for endoderm specification. We found that PI3K signalling promotes the transition from naïve endoderm precursors into committed anterior endoderm. PI3K promoted commitment via an atypical activity that delimited epithelial-to-mesenchymal transition (EMT). Akt1 transduced this activity via modifications to the extracellular matrix (ECM) and appropriate ECM could itself induce anterior endodermal identity in the absence of PI3K signalling. PI3K/Akt1-modified ECM contained low levels of Fibronectin (Fn1) and we found that Fn1 dose was key to specifying anterior endodermal identity in vivo and in vitro. Thus, localized PI3K activity affects ECM composition and ECM in turn patterns the endoderm. DOI: http://dx.doi.org/10.7554/eLife.00806.001.
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