ArticleJournal of molecular evolution2014
Prebiotic phosphate ester syntheses in a deep eutectic solvent.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life.Life (Basel, Switzerland) · 2026Review
- Magmatic immiscibility provides phosphate for prebiotic chemistry.Science advances · 2025Article
- Thermal Decomposition and Prebiotic Formation of Adenosine Phosphates in Simulated Early-Earth Evaporative Settings.Molecules (Basel, Switzerland) · 2025Article
- Qualitative Monitoring of Proto-Peptide Condensation by Differential FTIR Spectroscopy.ACS earth & space chemistry · 2024Article
- Prebiotic Syntheses of Organophosphorus Compounds from Reduced Source of Phosphorus in Non-Aqueous Solvents.Life (Basel, Switzerland) · 2023Article
- Prebiotic Chemistry of Phosphite: Mild Thermal Routes to Form Condensed-P Energy Currency Molecules Leading Up to the Formation of Organophosphorus Compounds.Life (Basel, Switzerland) · 2023Article
- Prebiotic Synthesis of ATP: A Terrestrial Volcanism-Dependent Pathway.Life (Basel, Switzerland) · 2023Article
- Review
- Phosphorylation in liquid sulfur dioxide under prebiotically plausible conditions.Communications chemistry · 2022Article
- A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry.Life (Basel, Switzerland) · 2022Review
- A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Prebiotic Chemistry: The Role of Trimetaphosphate in Prebiotic Chemical Evolution.Frontiers in chemistry · 2022Review
- From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth.Nature communications · 2021Article
- A physicochemical orthophosphate cycle via a kinetically stable thermodynamically activated intermediate enables mild prebiotic phosphorylations.Nature communications · 2021Article
- Coenzymes and Their Role in the Evolution of Life.Angewandte Chemie (International ed. in English) · 2021Review
- Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario.Life (Basel, Switzerland) · 2020Article
- The Prebiotic Provenance of Semi-Aqueous Solvents.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2020Article
- Deep Eutectic Solvents as Media for the Prebiotic DNA-Templated Synthesis of Peptides.Frontiers in chemistry · 2020Article
- Prebiotic Sugar Formation Under Nonaqueous Conditions and Mechanochemical Acceleration.Life (Basel, Switzerland) · 2019Article
- Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water.Life (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a route to synthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (2:1 urea and choline chloride), utilizing various orthophosphate sources. Heating an organic alcohol in the solvent along with a soluble phosphorus source yields phosphorus esters of choline as well as that of the added organic in yields between 15 to 99 %. In addition, phosphite analogs of biological phosphates and peptides were also formed by the simple mixing of reagents and heating at 60-70 °C in the deep eutectic solvent. The presented dehydration reactions are relevant to prebiotic and green chemistry in alternative solvents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.