Evidence map›Paper›PMID 24368573›Full record

SynthesisWorld journal of surgery2014

Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials.

Massimiliano Greco, Giovanni Capretti, Luigi Beretta, Marco Gemma, Nicolò Pecorelli, Marco Braga

8 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 357 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
357citing papers in PubMed, 18 pooled it
29.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02618811 completednot on this map

Enhanced Recovery After Surgery Protocol (ERAS) in Colorectal Surgery Diminishes the Negative Impact of Sarcopenia on Short Term Outcomes

TypeobservationalSponsorJagiellonian UniversityRan2014 to 2015Enrolled171ConditionsSarcopenia, Colonic Neoplasms
NCT02864277 nacompletednot on this mapstarted 2016, after this paper: background citation

Enhanced Recovery After Surgery (ERAS) Program Versus Conventional Perioperative Strategies in Patients Undergoing Gynecologic Oncologic Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorNorthwestern UniversityRan2016 to 2021Enrolled120ConditionsMalignant Female Reproductive System NeoplasmArmsNo Intervention Conventional Strategy, ERAS
NCT03382210 completednot on this map

Impact of a Colorectal Enhanced Recovery Program Implementation on Clinical Outcomes and Institutional Costs: A Prospective Cohort Study With Retrospective Control

TypeobservationalSponsorUniversity Hospital of FerraraRan2013 to 2016Enrolled200ConditionsColorectal Surgery, Recovery of Function, Laparoscopic SurgeryArmsEnhanced recovery protocol
NCT04037787 nacompletednot on this mapstarted 2019, after this paper: background citation

ERAS (Enhanced Recovery After Surgery) Protocol Implementation in Piedmont Region for Colorectal Cancer Surgery. A Stepped-wedge Cluster Randomized Clinical Trial

TypeinterventionalSponsorOspedale Santa Croce-Carle CuneoRan2019 to 2021Enrolled2,397ConditionsColorectal Cancer, Quality Improvement, Perioperative Care, Recovery of FunctionArmsERAS protocol
NCT04110080 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Enhanced Recovery After Surgery in Living Donor Kidney Transplant Donors

TypeinterventionalSponsorThomas Jefferson UniversityRan2019 to 2023Enrolled42ConditionsOpioid Use, Kidney Diseases, Pain, Postoperative, Postoperative ComplicationsArmsmultimodal pain management, goal directed fluid management, preoperative carbohydrate loading, Donor nephrectomy, regional anesthesia
NCT04625283 phase4completednot on this mapstarted 2021, after this paper: background citation

The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway

TypeinterventionalSponsorVanderbilt University Medical CenterRan2021 to 2024Enrolled1,570ConditionsOpioid Use, Enhanced Recovery After Surgery, Anesthesia, KetamineArmsKetamine, Placebo
NCT05522790 completednot on this mapstarted 2022, after this paper: background citation

Impact of Iron Infusion in Anemic Patients on Their Postoperative Outcome After Colorectal Surgery

TypeobservationalSponsorFondation Hôpital Saint-JosephRan2022 to 2023Enrolled270ConditionsAnemia, Iron Deficiency, Colorectal Surgery
NCT06409676 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Applicability of Enhanced Recovery After Surgery Protocols in the Therapeutic Endoscopy Suite: a Single-Center Randomized Prospective Study

TypeinterventionalSponsorIstituto Clinico HumanitasRan2024 to 2026Enrolled220ConditionsColorectal Endoscopic Submucosal DissectionArmsERAS protocols
3 · Its place in the literature

Who cites it

357 citing papers in PubMed, 18 syntheses or guidelines pooled it, 884 citations in OpenAlex.

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  10. Comparison of interventions and outcomes of enhanced recovery after surgery: a systematic review and meta-analysis of 2456 adolescent idiopathic scoliosis cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
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  11. Enhanced Recovery After Gastrointestinal Surgery (ERAS) in Pediatric Patients: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
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  14. [Enhanced recovery after surgery-Does the ERAS concept keep its promises].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
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297 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Massimiliano GrecoDepartment of Anesthesiology, San Raffaele Hospital, Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy, greco.massimiliano@hsr.it.
Giovanni Capretti
Luigi Beretta
Marco Gemma
Nicolò Pecorelli
Marco Braga
Vita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeta-analyses in the literature show that enhanced recovery after surgery (ERAS) is associated with lower morbidity rate and shorter hospital stay after elective colorectal surgery. However, a recent Cochrane review did not indicate the ERAS pathway as being the new standard of care due to the limited number of published trials, together with their poor quality. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess the impact of the ERAS pathway on overall morbidity, single postoperative complications, length of hospital stay, and readmission rate following colorectal surgery.

methodsWe searched BioMedCentral, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs comparing the ERAS pathway to conventional perioperative care. No language restrictions were considered. A quality score was calculated for each trial included.

resultsA total of 2,376 patients in 16 RCTs were included in the analysis. The ERAS pathway was associated with a reduction of overall morbidity [relative ratio (RR) = 0.60, (95 % CI 0.46-0.76)], particularly with respect to nonsurgical complications [RR = 0.40, (95 % CI 0.27-0.61)]. The reduction of surgical complications was not significant [RR = 0.76, (95 % CI 0.54-1.08)]. The ERAS pathway shortened hospital stay (WMD = -2.28 days [95 % CI -3.09 to -1.47]), without increasing readmission rate.

conclusionsThe ERAS pathway reduced overall morbidity rates and shortened the length of hospital stay, without increasing readmission rates. A significant reduction in nonsurgical complications was evident, while no significant reduction was found for surgical complications.

Indexed as

ColectomyColorectal NeoplasmsDisease-Free SurvivalFemaleHumansItalyLength of StayMalePatient Care TeamPatient ReadmissionPerioperative CarePrognosisProgram DevelopmentProgram EvaluationQuality ImprovementRandomized Controlled Trials as Topic

Identifiers

PMID24368573
OpenAlexW2016064861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.