ArticleMucosal immunology2014
Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development.
Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Eimeria: Navigating complex intestinal ecosystems.PLoS pathogens · 2024Review
- Study on the alleviative effect ofInfection and immunity · 2024Article
- Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host.Parasites & vectors · 2023Article
- Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells.Parasites & vectors · 2022Article
- Shifting focus from resistance to disease tolerance: A review on hybrid house mice.Ecology and evolution · 2022Review
- Eimeria proteins: order amidst disorder.Parasites & vectors · 2022Review
- Construction and Analysis of Coexpression Network to Understand Biological Responses in Chickens Infected byFrontiers in veterinary science · 2021Article
- Article
- Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii.Communications biology · 2020Article
- Effects of host fatty acid-binding protein 4 on Eimeria tenella sporozoites invasion of cells.Parasitology research · 2019Article
- iTRAQ-based comparative proteomic analysis of cells infected with Eimeria tenella sporozoites.Parasite (Paris, France) · 2019Article
- Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice.Infection and immunity · 2018Article
- Lipid analysis ofCell discovery · 2018Article
- Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses.BMC genomics · 2017Article
- Course of induced infection by Eimeria krijgsmannni in immunocompetent and immunodeficient mice.Parasitology research · 2016Article
- The genome of Eimeria falciformis--reduction and specialization in a single host apicomplexan parasite.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular parasites reprogram host functions for their survival and reproduction. The extent and relevance of parasite-mediated host responses in vivo remains poorly studied, however. We utilized Eimeria falciformis, a parasite infecting the mouse intestinal epithelium, to identify and validate host determinants of parasite infection. Most prominent mouse genes induced during the onset of asexual and sexual growth of parasite comprise interferon γ (IFNγ)-regulated factors, e.g., immunity-related GTPases (IRGA6/B6/D/M2/M3), guanylate-binding proteins (GBP2/3/5/6/8), chemokines (CxCL9-11), and several enzymes of the kynurenine pathway including indoleamine 2,3-dioxygenase 1 (IDO1). These results indicated a multifarious innate defense (tryptophan catabolism, IRG, GBP, and chemokine signaling), and a consequential adaptive immune response (chemokine-cytokine signaling and lymphocyte recruitment). The inflammation- and immunity-associated transcripts were increased during the course of infection, following influx of B cells, T cells, and macrophages to the parasitized caecum tissue. Consistently, parasite growth was enhanced in animals inhibited for CxCr3, a major receptor for CxCL9-11 present on immune cells. Interestingly, despite a prominent induction, mouse IRGB6 failed to bind and disrupt the parasitophorous vacuole, implying an immune evasion by E. falciformis. Furthermore, oocyst output was impaired in IFNγ-R(-/-) and IDO1(-/-) mice, both of which suggest a subversion of IFNγ signaling by the parasite to promote its growth.
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