ArticleDigestive diseases and sciences2014
Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- miR-127-3p Inhibits Cell Stemness and Docetaxel Resistance in Triple-Negative Breast Cancer by Targeting KIF3B.The Kaohsiung journal of medical sciences · 2026Article
- KIF3C inhibits the progression and proliferation of colorectal cancer.BMC gastroenterology · 2025Article
- Research progress of kinesin family in neurological diseases.Frontiers in cellular neuroscience · 2025Review
- The role of kinesin superfamily proteins in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2024Review
- Article
- The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside.Biomarker research · 2024Review
- The Prognostic and Therapeutic Roles of ARL-6 Gene in Hepatocellular Carcinoma.International journal of medical sciences · 2024Article
- KIF22 promotes bladder cancer progression by activating the expression of CDCA3.International journal of molecular medicine · 2021Article
- Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.The Kaohsiung journal of medical sciences · 2020Article
- Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.Cancer science · 2020Article
- Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.World journal of gastrointestinal oncology · 2020Article
- Carbohydrate response element binding protein (ChREBP) correlates with colon cancer progression and contributes to cell proliferation.Scientific reports · 2020Article
- Combined Use of Three Machine Learning Modeling Methods to Develop a Ten-Gene Signature for the Diagnosis of Ventilator-Associated Pneumonia.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.Journal of neuro-oncology · 2020Article
- KIF21B Expression in Osteosarcoma and Its Regulatory Effect on Osteosarcoma Cell Proliferation and Apoptosis Through the PI3K/AKT Pathway.Frontiers in oncology · 2020Article
- KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.Analytical cellular pathology (Amsterdam) · 2020Article
- KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.BioMed research international · 2020Article
- Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/Frontiers in oncology · 2020Article
- KIFC1 promotes the proliferation of hepatocellular carcinomaOncology letters · 2019Article
- Research progress on KIF3B and related diseases.Annals of translational medicine · 2019Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been involved in human carcinogenesis. KIF3B, the kinesin superfamily of proteins (KIFs), plays an important role in the regulation of mitotic progression.
aimThe expression of KIF3B and its involvement in HCC was investigated.
methodsWestern blot and immunohistochemistry were used to measure the expression of KIF3B protein in HCC and adjacent non-tumorous tissues in 57 patients and Cell Counting Kit-8 to analyze the effects of growth and interference of KIF3B in the cell cycle process.
resultsKIF3B protein level was increased in HCC tissues compared with the adjacent non-tumorous tissues. It was significantly associated with histological differentiation, tumor size, the level of alpha fetal protein (AFP) and proliferation marker Ki-67. Over-expression of KIF3B was correlated with poor survival. Following release of HepG2 cells from serum starvation, the expression of KIF3B was up-regulated. Furthermore, suppression of KIF3B not only decreased cancer cell growth but also induced apoptosis of cells.
conclusionsOur results suggested that KIF3B expression was upregulated in HCC tumor tissues and proliferating HCC cells, and an increased KIF3B expression was associated with poor overall survival. KIF3B over-expression is involved in the pathogenesis of hepatocellular carcinoma and may serve as a potential therapeutic target for human HCC.
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