ArticleHormones and behavior2014
Relationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain.
Article in Hormones and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety.Hormones and behavior · 2024Article
- Aromatase and nonaromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.The European journal of neuroscience · 2021Article
- Sexually differentiated and neuroanatomically specific co-expression of aromatase neurons and GAD67 in the male and female quail brain.The European journal of neuroscience · 2020Article
- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- New concepts in the study of the sexual differentiation and activation of reproductive behavior, a personal view.Frontiers in neuroendocrinology · 2019Review
- Differential control of appetitive and consummatory sexual behavior by neuroestrogens in male quail.Hormones and behavior · 2018Review
- Dual action of neuro-estrogens in the regulation of male sexual behavior.General and comparative endocrinology · 2018Review
- Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors.Frontiers in neuroscience · 2018Review
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Steroid metabolism in the brain: From bird watching to molecular biology, a personal journey.Hormones and behavior · 2017Review
- Glutamate released in the preoptic area during sexual behavior controls local estrogen synthesis in male quail.Psychoneuroendocrinology · 2017Article
- Rodent Models of Non-classical Progesterone Action Regulating Ovulation.Frontiers in endocrinology · 2017Review
- Article
- Actions of Steroids: New Neurotransmitters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Non-ovarian aromatization is required to activate female sexual motivation in testosterone-treated ovariectomized quail.Hormones and behavior · 2016Article
- In vivo visualization of aromatase in animals and humans.Frontiers in neuroendocrinology · 2016Review
- Estrogen Receptor β Activation Rapidly Modulates Male Sexual Motivation through the Transactivation of Metabotropic Glutamate Receptor 1a.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sex differences and rapid estrogen signaling: A look at songbird audition.Frontiers in neuroendocrinology · 2015Review
- The dual action of estrogen hypothesis.Trends in neurosciences · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Estradiol-17β (E2) synthesized in the brain plays a critical role in the activation of sexual behavior in many vertebrate species. Because E2 concentrations depend on aromatization of testosterone, changes in aromatase enzymatic activity (AA) are often utilized as a proxy to describe E2 concentrations. Utilizing two types of stimuli (sexual interactions and acute restraint stress) that have been demonstrated to reliably alter AA within minutes in opposite directions (sexual interactions=decrease, stress=increase), we tested in Japanese quail whether rapid changes in AA are paralleled by changes in E2 concentrations in discrete brain areas. In males, E2 in the pooled medial preoptic nucleus/medial portion of the bed nucleus of the stria terminalis (POM/BST) positively correlated with AA following sexual interactions. However, following acute stress, E2 decreased significantly (approximately 2-fold) in the male POM/BST despite a significant increase in AA. In females, AA positively correlated with E2 in both the POM/BST and mediobasal hypothalamus supporting a role for local, as opposed to ovarian, production regulating brain E2 concentrations. In addition, correlations of individual E2 in POM/BST and measurements of female sexual behavior suggested a role for local E2 synthesis in female receptivity. These data demonstrate that local E2 in the male brain changes in response to stimuli on a time course suggestive of potential non-genomic effects on brain and behavior. Overall, this study highlights the complex mechanisms regulating local E2 concentrations including rapid stimulus-driven changes in production and stress-induced changes in catabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.