Evidence map›Paper›PMID 24367955›Full record

SynthesisThe American journal of occupational therapy : official publication of the American Occupational Therapy Association

Systematic review of the effects of exercise on activities of daily living in people with Alzheimer's disease.

Ashwini K Rao, Aileen Chou, Brett Bursley, Jaclyn Smulofsky, Joel Jezequel

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of occupational therapy : official publication of the American Occupational Therapy Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02663934 (Exercise Training to Improve Brain Health in Older HIV+ Individuals), which is not on this map. Cited by 45 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02663934 naterminatednot on this map

Exercise Training to Improve Brain Health in Older HIV+ Individuals

TypeinterventionalSponsorWashington University School of MedicineRan2016 to 2020Enrolled75ConditionsHIVArmsExercise, Stretching and Social Interaction
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  16. Exercise to Counteract Alzheimer's Disease: What Do Fluid Biomarkers Say?International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ashwini K RaoAshwini K. Rao, EdD, OTR, FAOTA, is Associate Professor, Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy) and G. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, 8th Floor, New York, NY 10032; akr7@cumc.columbia.edu.
Aileen ChouAileen Chou, Brett Bursley, Jaclyn Smulofsky, and Joel Jezequel are Students, Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy), College of Physicians and Surgeons, Columbia University, New York.
Brett BursleyAileen Chou, Brett Bursley, Jaclyn Smulofsky, and Joel Jezequel are Students, Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy), College of Physicians and Surgeons, Columbia University, New York.
Jaclyn SmulofskyAileen Chou, Brett Bursley, Jaclyn Smulofsky, and Joel Jezequel are Students, Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy), College of Physicians and Surgeons, Columbia University, New York.
Joel JezequelAileen Chou, Brett Bursley, Jaclyn Smulofsky, and Joel Jezequel are Students, Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy), College of Physicians and Surgeons, Columbia University, New York.
Columbia University · US

Funding

Pathogenesis Of Essential Tremor: Cerebellar MetabolismR01NS042859 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOUIS, ELAN D · 2003 to 2012
$4.9M
Motor impairments in Huntington's disease: mechanisms and outcome measuresK01HD060912 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAO, ASHWINI K. · 2010 to 2013
$501k
NICHD NIH HHS 1K01HD060912NICHD NIH HHS K01 HD060912NINDS NIH HHS 5R01NS042859-06A2NINDS NIH HHS R01 NS042859
6 · The paper itself

Abstract

OBJECTIVE. Alzheimer's disease (AD) results in a loss of independence in activities of daily living (ADLs), which in turn affects the quality of life of affected people and places a burden on caretakers. Limited research has examined the influence of physical training (aerobic, balance, and strength training) on ADL performance of people with AD. METHOD. Six randomized controlled trials (total of 446 participants) fit the inclusion criteria. For each study, we calculated effect sizes for primary and secondary outcomes. RESULTS. Average effect size (95% confidence interval) for exercise on the primary outcome (ADL performance) was 0.80 (p < .001). Exercise had a moderate impact on the secondary outcome of physical function (effect size = 0.53, p = .004). CONCLUSION. Occupational therapy intervention that includes aerobic and strengthening exercises may help improve independence in ADLs and improve physical performance in people with AD. Additional research is needed to identify specific components of intervention and optimal dosage to develop clinical guidelines.

Indexed as

Activities of Daily LivingExercise TherapyOccupational TherapyAffectAlzheimer DiseaseCognitionEvidence-Based MedicineExercise TestHumansWalking

Identifiers

PMID24367955
PMCPMC5360200
OpenAlexW2139742477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.