Evidence map›Paper›PMID 24367787›Full record

ArticleInternational journal of genomics2013

TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population.

Xiao Yang, Pengchao Li, Xuejian Yang, Chao Qin, Qiang Cao, Zhengdong Zhang, Meilin Wang, Hongzhou Cai, Jinbao Gu, Jun Tao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiao YangDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Pengchao LiDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xuejian YangDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Chao QinDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Qiang CaoDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhengdong ZhangCancer Center of Nanjing Medical University, Department of Molecular & Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
Meilin WangCancer Center of Nanjing Medical University, Department of Molecular & Genetic Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
Hongzhou CaiDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jinbao GuDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jun TaoDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Min GuDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Qiang LuDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Changjun YinDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results. No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (P = 0.017). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions. In conclusion, TSP-1-1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population.

Identifiers

PMID24367787
PMCPMC3866825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.