Evidence map›Paper›PMID 24367620›Full record

SynthesisPloS one2013

Probiotics for preventing ventilator-associated pneumonia: a systematic review and meta-analysis of high-quality randomized controlled trials.

Jie Wang, Kai-xiong Liu, Felinda Ariani, Li-Li Tao, Jing Zhang, Jie-Ming Qu

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03074552 (Probiotic Prophylaxis for Microbiome Modulation and Ventilator Associated Pneumonia), which is not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03074552 nacompletednot on this mapstarted 2017, after this paper: background citation

Probiotic Prophylaxis for Microbiome Modulation and Ventilator Associated Pneumonia (VAP) or Severe Infections Prevention in Multitrauma Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Trial

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2017 to 2020Enrolled112ConditionsVentilator Associated Pneumonia, Infection, TraumaArmsLactoLevure, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  12. Probiotics in Critically Ill Patients: An Umbrella Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jie WangDepartment of Pulmonary Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Kai-xiong LiuDepartment of Pulmonary Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.
Felinda ArianiDepartment of Pulmonary Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Li-Li TaoDepartment of Pulmonary Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Jing ZhangDepartment of Pulmonary Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Jie-Ming QuDepartment of Pulmonary Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Fudan University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVentilator-associated pneumonia (VAP) is considered to be a worldwide issue along with the development of supportive ventilation. The preventing strategy is of great importance for its poor prognostic and difficulties in treatment. Probiotics have been advocated as one of the possible preventive measures. We conducted a systematic review and meta-analysis to explore the potential benefits of probiotics.

methodsThe databases, Web of science, PubMed, Ovid and Cochrane lib were searched for randomized controlled trials (RCTs) publications that compared the effectiveness of probiotics with placebo in the prevention of VAP. The incidence of VAP was considered as the primary endpoint, mortality, length of stay in intensive care units (ICUs), etiology of the infections were considered as secondary endpoints.

resultsA total of 844 patients from 5 trials were subjected to meta-analysis. Probiotics did not significantly decrease the incidence of VAP (RR 0.94, 95%CI 0.85-1.04, p=0.22), however, the administration of probiotics reduced the risk of VAP caused by Pseudomonas aeruginosa (P. aeruginosa) (RR 0.30, 95%CI 0.11-0.91, P=0.03). It failed to affect any other endpoints.

conclusionProbiotic prophylaxis of ventilator-associated pneumonia remained inconclusive and it failed to improve the prognosis of general mechanically ventilated patients. It was noteworthy that infections caused by P. aeruginosa was reduced by administration of probiotics. In further, it is recommended that advanced studies should exploit transformation in pathogenic microorganisms owing to administration of probiotics as well as the specific population.

Indexed as

HumansPneumonia, Ventilator-AssociatedProbioticsQuality ControlRandomized Controlled Trials as Topic

Identifiers

PMID24367620
PMCPMC3867481
OpenAlexW2080460653

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.