ArticlePloS one2013
An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 90 citations in OpenAlex.
- A genome sequence and efficient CRISPR/Cas9 gene editing tools for the solanaceous specialist pest Tetranychus evansi.Insect biochemistry and molecular biology · 2026Article
- Insight into the Prospects of RNA Interference for Honey Bee Pathogens and Parasite Control.Insects · 2026Review
- A complete genome sequence enables efficient genetic mapping of adaptive traits in a phytoseiid predatory mite (Amblyseius andersoni).Communications biology · 2026Article
- Drugs and products in beekeeping: Efficacy and perspectives of natural alternatives.Veterinarni medicina · 2026Review
- Widespread pyrethroid resistance in Varroa destructor in Türkiye: a molecular warning.Experimental & applied acarology · 2026Article
- Snapback high resolution melting analysis for the rapid detection and differentiation of the L925 mutations associated with resistance to synthetic pyrethroids in Varroa destructor.Experimental & applied acarology · 2026Article
- Response of Amblyseius swirskii to deltamethrin.Pest management science · 2025Article
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- Sensitivity and Resistance of Parasitic Mites (Insects · 2025Review
- The status of pyrethroid resistance mutation frequencies in Varroa destructor populations in the most important beekeeping areas of Türkiye.Experimental & applied acarology · 2025Article
- Arising amitraz and pyrethroids resistance mutations in the ectoparasitic Varroa destructor mite in Canada.Scientific reports · 2025Article
- A new mutation in the octopamine receptor associated with amitraz resistance in Varroa destructor.Pest management science · 2025Article
- Amitraz Resistance in FrenchInsects · 2024Article
- Evaluating the seasonal efficacy of commonly used chemical treatments on Varroa destructor (Mesostigmata: Varroidae) population resurgence in honey bee colonies.Journal of insect science (Online) · 2024Article
- Geographical distribution of pyrethroid resistance mutations in Varroa destructor across Türkiye and a European overview.Experimental & applied acarology · 2024Article
- Varroa destructor resistance to tau-fluvalinate: relationship between in vitro phenotypic test and VGSC L925V mutation.Pest management science · 2022Article
- Utility and challenges of using whole-genome resequencing to detect emerging insect and mite resistance in agroecosystems.Evolutionary applications · 2022Review
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Varroa mite, Varroa destructor, is an important pest of honeybees and has played a prominent role in the decline in bee colony numbers over recent years. Although pyrethroids such as tau-fluvalinate and flumethrin can be highly effective in removing the mites from hives, their intensive use has led to many reports of resistance. To investigate the mechanism of resistance in UK Varroa samples, the transmembrane domain regions of the V. destructor voltage-gated sodium channel (the main target site for pyrethroids) were PCR amplified and sequenced from pyrethroid treated/untreated mites collected at several locations in Central/Southern England. A novel amino acid substitution, L925V, was identified that maps to a known hot spot for resistance within the domain IIS5 helix of the channel protein; a region that has also been proposed to form part of the pyrethroid binding site. Using a high throughput diagnostic assay capable of detecting the mutation in individual mites, the L925V substitution was found to correlate well with resistance, being present in all mites that had survived tau-fluvalinate treatment but in only 8 % of control, untreated samples. The potential for using this assay to detect and manage resistance in Varroa-infected hives is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.