ArticlePloS one2013
Recombination and evolution of duplicate control regions in the mitochondrial genome of the Asian big-headed turtle, Platysternon megacephalum.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 30 citations in OpenAlex.
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- Insights into Mitochondrial Rearrangements and Selection in Accipitrid Mitogenomes, with New Data onGenes · 2024Article
- Characterization of the Complete Mitochondrial Genome ofAnimals : an open access journal from MDPI · 2024Article
- Two-FoldAnimals : an open access journal from MDPI · 2023Article
- Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle.iScience · 2023Article
- Comparative Mitogenomic Analysis of Two Snake Eels Reveals Irregular Gene Rearrangement and Phylogenetic Implications of Ophichthidae.Animals : an open access journal from MDPI · 2023Article
- A Novel Mitochondrial Genome Fragmentation Pattern in the Buffalo LouseInternational journal of molecular sciences · 2022Article
- Complete Mitogenomes ofAnimals : an open access journal from MDPI · 2022Article
- Concerted and Independent Evolution of Control Regions 1 and 2 of Water Monitor Lizards (Animals : an open access journal from MDPI · 2022Article
- Structural Variation of the Turtle Mitochondrial Control Region.Journal of molecular evolution · 2020Article
- First record of a tandem-repeat region within the mitochondrial genome of Clonorchis sinensis using a long-read sequencing approach.PLoS neglected tropical diseases · 2020Article
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- The first complete mitochondrial genome of the Indian Tent Turtle,Ecology and evolution · 2019Article
- The Complete Mitochondrial Genome ofGenes · 2019Article
- Long-read sequencing reveals a 4.4 kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1.Parasites & vectors · 2019Article
- Draft genome of the big-headed turtle Platysternon megacephalum.Scientific data · 2019Article
- Complete mitochondrial genome of Black Soft-shell Turtle (Nilssonia nigricans) and comparative analysis with other Trionychidae.Scientific reports · 2018Article
- Single-molecule long-read transcriptome profiling of Platysternon megacephalum mitochondrial genome with gene rearrangement and control region duplication.RNA biology · 2018Article
- Comparative Mitogenomic Analyses of Praying Mantises (Dictyoptera, Mantodea): Origin and Evolution of Unusual Intergenic Gaps.International journal of biological sciences · 2017Article
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7 authors at 1 institution in 1 country.
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Abstract
Complete mitochondrial (mt) genome sequences with duplicate control regions (CRs) have been detected in various animal species. In Testudines, duplicate mtCRs have been reported in the mtDNA of the Asian big-headed turtle, Platysternon megacephalum, which has three living subspecies. However, the evolutionary pattern of these CRs remains unclear. In this study, we report the completed sequences of duplicate CRs from 20 individuals belonging to three subspecies of this turtle and discuss the micro-evolutionary analysis of the evolution of duplicate CRs. Genetic distances calculated with MEGA 4.1 using the complete duplicate CR sequences revealed that within turtle subspecies, genetic distances between orthologous copies from different individuals were 0.63% for CR1 and 1.2% for CR2app:addword:respectively, and the average distance between paralogous copies of CR1 and CR2 was 4.8%. Phylogenetic relationships were reconstructed from the CR sequences, excluding the variable number of tandem repeats (VNTRs) at the 3' end using three methods: neighbor-joining, maximum likelihood algorithm, and Bayesian inference. These data show that any two CRs within individuals were more genetically distant from orthologous genes in different individuals within the same subspecies. This suggests independent evolution of the two mtCRs within each P. megacephalum subspecies. Reconstruction of separate phylogenetic trees using different CR components (TAS, CD, CSB, and VNTRs) suggested the role of recombination in the evolution of duplicate CRs. Consequently, recombination events were detected using RDP software with break points at ≈290 bp and ≈1,080 bp. Based on these results, we hypothesize that duplicate CRs in P. megacephalum originated from heterological ancestral recombination of mtDNA. Subsequent recombination could have resulted in homogenization during independent evolutionary events, thus maintaining the functions of duplicate CRs in the mtDNA of P. megacephalum.
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