ArticlePloS one2013
Zinc deficiency is common in several psychiatric disorders.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Zinc in psychosis (Review).Molecular medicine reports · 2025Review
- Dysregulated zinc homeostasis and microadenomas in the anterior pituitary: pathological insights into suicide risk.Frontiers in psychiatry · 2024Article
- Evaluation of Antidepressive-like Behaviours and Oxidative Stress Parameters in Mice Receiving Imipramine-Zinc Complex Compound.International journal of molecular sciences · 2023Article
- Key Nutrients for Optimal Blood Glucose Control and Mental Health in Individuals with Diabetes: A Review of the Evidence.Nutrients · 2023Review
- Prevalence of low dietary zinc intake in women and pregnant women in Ireland.Irish journal of medical science · 2023Article
- The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications.Cellular and molecular neurobiology · 2023Review
- Association between Dietary Zinc Intake, Serum Zinc Level and Multiple Comorbidities in Older Adults.Nutrients · 2023Article
- Zinc as a Neuroprotective Nutrient for COVID-19-Related Neuropsychiatric Manifestations: A Literature Review.Advances in nutrition (Bethesda, Md.) · 2022Review
- Article
- Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment.World journal of clinical cases · 2021Review
- Dietary zinc supplement militates against ketamine-induced behaviours by age-dependent modulation of oxidative stress and acetylcholinesterase activity in mice.Pharmacological reports : PR · 2020Article
- Vitamin D deficiency mediates the relationship between dietary patterns and depression: a case-control study.Annals of general psychiatry · 2020Article
- Antidepressant, Anxiolytic and Neuroprotective Activities of Two Zinc Compounds in Diabetic Rats.Frontiers in neuroscience · 2019Article
- Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study.BMC psychiatry · 2018Article
- Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.Therapeutic advances in gastroenterology · 2018Article
- Effects of proteinate complex zinc on growth performance, hepatic and splenic trace elements concentrations, antioxidative function and immune functions in weaned piglets.Asian-Australasian journal of animal sciences · 2017Article
- The serum zinc concentration as a potential biological marker in patients with major depressive disorder.Metabolic brain disease · 2017Article
- Infants and elderlies are susceptible to zinc deficiency.Scientific reports · 2016Article
- Risk of malnutrition and zinc deficiency in community-living elderly men and women: the Tromsø Study.Public health nutrition · 2015Article
- Zinc in the Glutamatergic Theory of Depression.Current neuropharmacology · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMounting evidence suggests a link between low zinc levels and depression. There is, however, little knowledge about zinc levels in older persons with other psychiatric diagnoses. Therefore, we explore the zinc status of elderly patients suffering from a wide range of psychiatric disorders.
methodsClinical data and blood samples for zinc analyzes were collected from 100 psychogeriatric patients over 64 of age. Psychiatric and cognitive symptoms were assessed using the Montgomery and Aasberg Depression Rating Scale, the Cornell Scale for Depression in Dementia, the Mini-Mental State Examination, the Clockdrawing Test, clinical interviews and a review of medical records. In addition, a diagnostic interview was conducted using the Mini International Neuropsychiatric Interview instrument. The prevalence of zinc deficiency in patients with depression was compared with the prevalence in patients without depression, and the prevalence in a control group of 882 older persons sampled from a population study.
resultsThere was a significant difference in zinc deficiency prevalence between the control group (14.4%) and the patient group (41.0%) (χ(2) = 44.81, df = 1, p<0.001). In a logistic model with relevant predictors, zinc deficiency was positively associated with gender and with serum albumin level. The prevalence of zinc deficiency in the patient group was significantly higher in patients without depression (i.e. with other diagnoses) than in patients with depression as a main diagnosis or comorbid depression (χ(2) = 4.36, df = 1, p = 0.037).
conclusionsZinc deficiency is quite common among psychogeriatric patients and appears to be even more prominent in patients suffering from other psychiatric disorders than depression. LIMITATIONS: This study does not provide a clear answer as to whether the observed differences represent a causal relationship between zinc deficiency and psychiatric symptoms. The blood sample collection time points varied in both the control group and the patient group. No data regarding zinc supplementation were collected.
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