ArticlePloS one2013
Specific multilocus variable-number tandem-repeat analysis genotypes of Mycoplasma pneumoniae are associated with diseases severity and macrolide susceptibility.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Host inflammatory markers and MLVA profiling for risk assessment of severe pediatricFrontiers in cellular and infection microbiology · 2026Article
- IncreasedFrontiers in cellular and infection microbiology · 2024Article
- Current status of Mycoplasma pneumoniae infection in China.World journal of pediatrics : WJP · 2024Article
- Characteristics of theAntibiotics (Basel, Switzerland) · 2023Article
- The Association betweenMicroorganisms · 2023Article
- Molecular Tools for TypingFrontiers in microbiology · 2022Review
- Macrolide Resistance, Clinical Features, and Cytokine Profiles in Taiwanese Children WithOpen forum infectious diseases · 2021Article
- Article
- Increased Macrolide Resistance Rate of M3562Frontiers in cellular and infection microbiology · 2021Article
- Antimicrobial susceptibility and molecular characteristics ofAntimicrobial resistance and infection control · 2019Article
- Antimicrobial susceptibility and genotyping ofAntimicrobial resistance and infection control · 2019Article
- Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Comparison of the molecular characteristics of Mycoplasma pneumoniae from children across different regions of China.PloS one · 2018Article
- Genotyping and macrolide resistance of Mycoplasma pneumoniae identified in children with community-acquired pneumonia in Medellín, Colombia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2018Article
- [Association of drug resistance of Mycoplasma pneumoniae with DNA load and genotypes in children with Mycoplasma pneumoniae pneumonia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Pediatric clinical features ofExperimental and therapeutic medicine · 2017Article
- Mycoplasma pneumoniae from the Respiratory Tract and Beyond.Clinical microbiology reviews · 2017Review
- Changes in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015.PloS one · 2017Article
- The Evolution of Advanced Molecular Diagnostics for the Detection and Characterization of Mycoplasma pneumoniae.Frontiers in microbiology · 2016Review
- Comparison of Molecular Characteristics of Mycoplasma pneumoniae Specimens Collected from the United States and China.Journal of clinical microbiology · 2015Article
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7 authors.
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Abstract
Clinical relevance of multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) in patients with community-acquired pneumonia (CAP) by Mycoplasma pneumoniae (M. pneumoniae) is unknown. A multi-center, prospective study was conducted from November 2010 to April 2012. Nine hundred and fifty-four CAP patients were consecutively enrolled. M. pneumoniae clinical isolates were obtained from throat swabs. MLVA typing was applied to all isolates. Comparison of pneumonia severity index (PSI) and clinical features among patients infected with different MLVA types of M. pneumoniae were conducted. One hundred and thirty-six patients were positive with M. pneumoniae culture. The clinical isolates were clustered into 18 MLVA types. One hundred and fourteen (88.3%) isolates were resistant to macrolide, covering major MLVA types. The macrolide non-resistant rate of M. pneumoniae isolates with Mpn13-14-15-16 profile of 3-5-6-2 was significantly higher than that of other types (p ≤ 0.001). Patients infected with types U (5-4-5-7-2) and J (3-4-5-7-2) had significantly higher PSI scores (p<0.001) and longer total duration of cough (p = 0.011). Therefore it seems that there is a correlation between certain MLVA types and clinical severity of disease and the presence of macrolide resistance.
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