ReviewFrontiers in immunology2013
Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Article
- The effects of physical exercise on inflammation-induced maladaptive neuroplasticity in post-traumatic headache.Neuroscience · 2026Review
- GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment.Frontiers in immunology · 2026Article
- IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HRNature cancer · 2025Article
- γδ T Cells and Allergic Diseases.Clinical reviews in allergy & immunology · 2023Review
- Intestinal commensal microbiota and cytokines regulate Fut2Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity.Cellular & molecular immunology · 2021Article
- Adjustments of γδ T Cells in the Lung ofFrontiers in immunology · 2020Article
- Early production of IL-17A by γδ T cells in the trachea promotes viral clearance during influenza infection in mice.European journal of immunology · 2020Article
- Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.PLoS biology · 2018Article
- HEB is required for the specification of fetal IL-17-producing γδ T cells.Nature communications · 2017Article
- Recruitment of Neutrophils Mediated by Vγ2 γδ T Cells Deteriorates Liver Fibrosis Induced by Schistosoma japonicum Infection in C57BL/6 Mice.Infection and immunity · 2017Article
- IL-17Nature immunology · 2017Review
- Activation and selective IL-17 response of human Vγ9Vδ2 T lymphocytes by TLR-activated plasmacytoid dendritic cells.Oncotarget · 2016Article
- The CD4(+) T cell methylome contributes to a distinct CD4(+) T cell transcriptional signature in Mycobacterium bovis-infected cattle.Scientific reports · 2016Article
- CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.Nature immunology · 2016Article
- IL-17-producing γδ T cells enhance bone regeneration.Nature communications · 2016Article
- Characterization of lung infection-induced TCRγδ T cell phenotypes by CyTOF mass cytometry.Journal of leukocyte biology · 2016Article
- PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Immune mechanisms in acetaminophen-induced acute liver failure.Hepatobiliary surgery and nutrition · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
γδ T cells are unconventional innate-like lymphocytes that actively participate in protective immunity against tumors and infectious organisms including bacteria, viruses, and parasites. However, γδ T cells are also involved in the development of inflammatory and autoimmune diseases. γδ T cells are functionally characterized by very rapid production of pro-inflammatory cytokines, while also impacting on (slower but long-lasting) adaptive immune responses. This makes it crucial to understand the molecular mechanisms that regulate γδ T cell effector functions. Although they share many similarities with αβ T cells, our knowledge of the molecular pathways that control effector functions in γδ T cells still lags significantly behind. In this review, we focus on the segregation of interferon-γ versus interleukin-17 production in murine thymic-derived γδ T cell subsets defined by CD27 and CCR6 expression levels. We summarize the most recent studies that disclose the specific epigenetic and transcriptional mechanisms that govern the stability or plasticity of discrete pro-inflammatory γδ T cell subsets, whose manipulation may be valuable for regulating (auto)immune responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.