ArticleFrontiers in aging neuroscience2013
High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Iron deficiency anemia perturbs erythrocyte morphology and may promote eryptosis.International journal of hematology · 2026Article
- Red Blood Cell-Derived Exosomes as Mediators of Age-Related Neurodegeneration.Rejuvenation research · 2025Article
- Blood-based biomarkers in mild behavioral impairment: an updated overview.Frontiers in neurology · 2025Review
- Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes.Journal of advanced research · 2024Article
- Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.Aging and disease · 2024Review
- Exploring theResearch and practice in thrombosis and haemostasis · 2024Article
- Morphometric and Nanomechanical Screening of Peripheral Blood Cells with Atomic Force Microscopy for Label-Free Assessment of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2023Review
- Alterations in hematological parameters and the structure of peripheral erythrocytes in Nile tilapia (Oreochromis niloticus) exposed to profenofos.Environmental science and pollution research international · 2022Article
- Sensing red blood cell nano-mechanics: Toward a novel blood biomarker for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Morphometry and Stiffness of Red Blood Cells-Signatures of Neurodegenerative Diseases and Aging.International journal of molecular sciences · 2021Article
- Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis.Metabolites · 2021Review
- Alteration of Iron Concentration in Alzheimer's Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis.International journal of molecular sciences · 2021Review
- Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions.Microorganisms · 2020Review
- Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease.Aging · 2019Article
- Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus.Scientific reports · 2018Article
- Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.Molecular psychiatry · 2018Article
- Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.Frontiers in neuroscience · 2018Review
- The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia.Frontiers in aging neuroscience · 2018Article
- Red blood cell distribution width as a prognostic marker in patients with heart failure and diabetes mellitus.Cardiovascular diabetology · 2017Article
- The stabilizing effect of an oligomeric proanthocyanidin on red blood cell membrane structure of poorly controlled Type II diabetes.Nutrition & diabetes · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUnliganded iron both contributes to the pathology of Alzheimer's disease (AD) and also changes the morphology of erythrocytes (RBCs). We tested the hypothesis that these two facts might be linked, i.e., that the RBCs of AD individuals have a variant morphology, that might have diagnostic or prognostic value.
methodsWe included a literature survey of AD and its relationships to the vascular system, followed by a laboratory study. Four different microscopy techniques were used and results statistically compared to analyze trends between high and normal serum ferritin (SF) AD individuals.
resultsLight and scanning electron microscopies showed little difference between the morphologies of RBCs taken from healthy individuals and from normal SF AD individuals. By contrast, there were substantial changes in the morphology of RBCs taken from high SF AD individuals. These differences were also observed using confocal microscopy and as a significantly greater membrane stiffness (measured using force-distance curves).
conclusionWe argue that high ferritin levels may contribute to an accelerated pathology in AD. Our findings reinforce the importance of (unliganded) iron in AD, and suggest the possibility both of an early diagnosis and some means of treating or slowing down the progress of this disease.
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