ReviewFrontiers in synaptic neuroscience2013
Target-cell-specific short-term plasticity in local circuits.
Review in Frontiers in synaptic neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Distinct modes of dopamine modulation on striatopallidal synaptic transmission.Nature communications · 2026Article
- A bio-inspired minimal model for non-stationary K-armed bandits.Biological cybernetics · 2026Article
- Editorial: The diversity of the plasticitome.Frontiers in synaptic neuroscience · 2026Article
- Cell Type-Dependent Short-Term Plasticity and Dopaminergic Modulation of Sensory Synapses onto Mouse Superficial Dorsal Horn Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Lateralized local circuit tuning in female mouse auditory cortex.Neuroscience research · 2025Article
- Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells.Communications biology · 2025Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Principles of visual cortex excitatory microcircuit organization.Innovation (Cambridge (Mass.)) · 2025Article
- Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells.Frontiers in synaptic neuroscience · 2025Article
- Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.Cell reports · 2024Article
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Frontiers in cellular neuroscience · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- The short-term plasticity of VIP interneurons in motor cortex.Frontiers in synaptic neuroscience · 2024Article
- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Comparing mouse and human brains.eLife · 2023Article
- Article
- Unitary synaptic responses of parvalbumin interneurons evoked by excitatory neurons in the mouse barrel cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Bicuculline restores frequency-dependent hippocampal I/E ratio and circuit function in PGC-1ɑ null mice.Neuroscience research · 2022Article
- Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning.PLoS computational biology · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Short-term plasticity (STP) denotes changes in synaptic strength that last up to tens of seconds. It is generally thought that STP impacts information transfer across synaptic connections and may thereby provide neurons with, for example, the ability to detect input coherence, to maintain stability and to promote synchronization. STP is due to a combination of mechanisms, including vesicle depletion and calcium accumulation in synaptic terminals. Different forms of STP exist, depending on many factors, including synapse type. Recent evidence shows that synapse dependence holds true even for connections that originate from a single presynaptic cell, which implies that postsynaptic target cell type can determine synaptic short-term dynamics. This arrangement is surprising, since STP itself is chiefly due to presynaptic mechanisms. Target-specific synaptic dynamics in addition imply that STP is not a bug resulting from synapses fatiguing when driven too hard, but rather a feature that is selectively implemented in the brain for specific functional purposes. As an example, target-specific STP results in sequential somatic and dendritic inhibition in neocortical and hippocampal excitatory cells during high-frequency firing. Recent studies also show that the Elfn1 gene specifically controls STP at some synapse types. In addition, presynaptic NMDA receptors have been implicated in synapse-specific control of synaptic dynamics during high-frequency activity. We argue that synapse-specific STP deserves considerable further study, both experimentally and theoretically, since its function is not well known. We propose that synapse-specific STP has to be understood in the context of the local circuit, which requires combining different scientific disciplines ranging from molecular biology through electrophysiology to computer modeling.
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