ReviewFrontiers in neuroenergetics2013
(13)C NMR spectroscopy applications to brain energy metabolism.
Review in Frontiers in neuroenergetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.NMR in biomedicine · 2026Article
- Feasibility of Deuterium Metabolic Magnetic Resonance Spectroscopy for the Investigation of Ischemia and Reperfusion in Rat Brain Slices Perfused Ex Vivo.NMR in biomedicine · 2025Article
- Effect and mechanism of Dichloroacetate in the treatment of stroke and the resolution strategy for side effect.European journal of medical research · 2025Review
- Astrocytic CaGlia · 2024Article
- In VivoNeurochemical research · 2022Review
- CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?Cell & bioscience · 2021Review
- Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder.Frontiers in psychiatry · 2021Review
- Pyruvate-lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1-NMR in biomedicine · 2020Article
- Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism.Scientific reports · 2018Article
- Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-Scientific reports · 2018Article
- Review
- Lactate in the brain: from metabolic end-product to signalling molecule.Nature reviews. Neuroscience · 2018Review
- Article
- Consumption of Alcopops During Brain Maturation Period: Higher Impact of Fructose Than Ethanol on Brain Metabolism.Frontiers in nutrition · 2018Article
- Twenty-seven Years of Cerebral Pyruvate Recycling.Neurochemical research · 2017Review
- Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Review
- Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
(13)C nuclear magnetic resonance (NMR) spectroscopy is the method of choice for studying brain metabolism. Indeed, the most convincing data obtained to decipher metabolic exchanges between neurons and astrocytes have been obtained using this technique, thus illustrating its power. It may be difficult for non-specialists, however, to grasp thefull implication of data presented in articles written by spectroscopists. The aim of the review is, therefore, to provide a fundamental understanding of this topic to facilitate the non-specialists in their reading of this literature. In the first part of this review, we present the metabolic fate of (13)C-labeled substrates in the brain in a detailed way, including an overview of some general neurochemical principles. We also address and compare the various spectroscopic strategies that can be used to study brain metabolism. Then, we provide an overview of the (13)C NMR experiments performed to analyze both intracellular and intercellular metabolic fluxes. More particularly, the role of lactate as a potential energy substrate for neurons is discussed in the light of (13)C NMR data. Finally, new perspectives and applications offered by (13)C hyperpolarization are described.
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