ArticleFrontiers in behavioral neuroscience2013
Mouse Grueneberg ganglion neurons share molecular and functional features with C. elegans amphid neurons.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
- Hydrogen sulfide as a potent predator-derived kairomone mediating fear-related responses in mice.Communications biology · 2025Article
- Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.International journal of molecular sciences · 2024Article
- From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion.Animals : an open access journal from MDPI · 2022Article
- Food preference acquired by social transmission is altered by the absence of the olfactory marker protein in mice.Frontiers in nutrition · 2022Article
- Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms.Communications biology · 2021Article
- The Grueneberg ganglion controls odor-driven food choices in mice under threat.Communications biology · 2020Article
- Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.BMC biology · 2018Article
- Guanylyl cyclase-G is an alarm pheromone receptor in mice.The EMBO journal · 2018Article
- Article
- Grueneberg Glomeruli in the Olfactory Bulb are Activated by Odorants and Cool Temperature.Cellular and molecular neurobiology · 2017Article
- Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis.Journal of visualized experiments : JoVE · 2016Article
- Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse.Frontiers in behavioral neuroscience · 2016Article
- Integrating temperature with odor processing in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.The EMBO journal · 2015Article
- Identification of pyridine analogs as new predator-derived kairomones.Frontiers in neuroscience · 2015Article
- Olfactory memory networks: from emotional learning to social behaviors.Frontiers in behavioral neuroscience · 2015Article
- Morphological and physiological species-dependent characteristics of the rodent Grueneberg ganglion.Frontiers in neuroanatomy · 2014Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The mouse Grueneberg ganglion (GG) is an olfactory subsystem located at the tip of the nose close to the entry of the naris. It comprises neurons that are both sensitive to cold temperature and play an important role in the detection of alarm pheromones (APs). This chemical modality may be essential for species survival. Interestingly, GG neurons display an atypical mammalian olfactory morphology with neurons bearing deeply invaginated cilia mostly covered by ensheathing glial cells. We had previously noticed their morphological resemblance with the chemosensory amphid neurons found in the anterior region of the head of Caenorhabditis elegans (C. elegans). We demonstrate here further molecular and functional similarities. Thus, we found an orthologous expression of molecular signaling elements that was furthermore restricted to similar specific subcellular localizations. Calcium imaging also revealed a ligand selectivity for the methylated thiazole odorants that amphid neurons are known to detect. Cellular responses from GG neurons evoked by chemical or temperature stimuli were also partially cGMP-dependent. In addition, we found that, although behaviors depending on temperature sensing in the mouse, such as huddling and thermotaxis did not implicate the GG, the thermosensitivity modulated the chemosensitivity at the level of single GG neurons. Thus, the striking similarities with the chemosensory amphid neurons of C. elegans conferred to the mouse GG neurons unique multimodal sensory properties.
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