ReviewFrontiers in behavioral neuroscience2013
The amygdala: securing pleasure and avoiding pain.
Review in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.Psychiatry research. Neuroimaging · 2020Pooled it
- Building neuroanatomical resources for three-spined sticklebacks: Brain areas important for social behavior.bioRxiv : the preprint server for biology · 2026Article
- The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures.Journal of neurochemistry · 2025Article
- Brain representations of affective valence and intensity in sustained pleasure and pain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The projection from dorsal medial prefrontal cortex to basolateral amygdala promotes behaviors of negative emotion in rats.Frontiers in neuroscience · 2024Article
- Proteomic Analysis of the Amygdala Reveals Dynamic Changes in Glutamate Transporter-1 During Progression of Complete Freund's Adjuvant-Induced Pain Aversion.Molecular neurobiology · 2023Article
- Reduced grey matter volume in adolescents with conduct disorder: a region-of-interest analysis using multivariate generalized linear modeling.Discover mental health · 2023Article
- Reduced Grey Matter Volume in Adolescents with Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling.Research square · 2023Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Synaptic plasticity in two cell types of central amygdala for regulation of emotion and pain.Frontiers in cellular neuroscience · 2022Article
- Early social adversity modulates the relation between attention biases and socioemotional behaviour in juvenile macaques.Scientific reports · 2021Article
- Incentive motivation: 'wanting' roles of central amygdala circuitry.Behavioural brain research · 2021Review
- Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.Behavioural brain research · 2021Review
- A Circuit-Based Information Approach to Substance Abuse Research.Trends in neurosciences · 2021Review
- Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure toFrontiers in behavioral neuroscience · 2021Article
- Article
- Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity.European journal of pain (London, England) · 2020Article
- Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?Psychiatry research. Neuroimaging · 2020Article
- Cell-Type- and Endocannabinoid-Specific Synapse Connectivity in the Adult Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The amygdala has traditionally been associated with fear, mediating the impact of negative emotions on memory. However, this view does not fully encapsulate the function of the amygdala, nor the impact that processing in this structure has on the motivational limbic corticostriatal circuitry of which it is an important structure. Here we discuss the interactions between different amygdala nuclei with cortical and striatal regions involved in motivation; interconnections and parallel circuitries that have become increasingly understood in recent years. We review the evidence that the amygdala stores memories that allow initially motivationally neutral stimuli to become associated through pavlovian conditioning with motivationally relevant outcomes which, importantly, can be either appetitive (e.g. food) or aversive (e.g. electric shock). We also consider how different psychological processes supported by the amygdala such as conditioned reinforcement and punishment, conditioned motivation and suppression, and conditioned approach and avoidance behavior, are not only psychologically but also neurobiologically dissociable, being mediated by distinct yet overlapping neural circuits within the limbic corticostriatal circuitry. Clearly the role of the amygdala goes beyond encoding aversive stimuli to also encode the appetitive, requiring an appreciation of the amygdala's mediation of both appetitive and fearful behavior through diverse psychological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.