Evidence map›Paper›PMID 24367304›Full record

ArticleFrontiers in behavioral neuroscience2013

Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus.

Megan E Olshavsky, Bryan J Song, Daniel J Powell, Carolyn E Jones, Marie-H Monfils, Hongjoo J Lee

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In one paragraph

Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. COAddiction biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  14. Disrupting reconsolidation: memory erasure or blunting of emotional/motivational value?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. An Update on Memory Reconsolidation Updating.Trends in cognitive sciences · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megan E OlshavskyDepartment of Psychology, The University of Texas at Austin Austin, TX, USA.
Bryan J SongDepartment of Psychology, The University of Texas at Austin Austin, TX, USA.
Daniel J PowellDepartment of Psychology, The University of Texas at Austin Austin, TX, USA.
Carolyn E JonesDepartment of Psychology, The University of Texas at Austin Austin, TX, USA.
Marie-H MonfilsDepartment of Psychology, The University of Texas at Austin Austin, TX, USA ; Center for Learning and Memory, The University of Texas at Austin Austin, TX, USA.
Hongjoo J LeeDepartment of Psychology, The University of Texas at Austin Austin, TX, USA.

Funding

Fear memory attenuation: testing reconsolidation-extinction boundariesR01MH091147 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI MONFILS, MARIE H. · 2011 to 2015
$1.9M
Novel paradigm attenuates traumatic memories and prevents return of fearR21MH086805 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI MONFILS, MARIE H. · 2010 to 2011
$398k
NIMH NIH HHS R01 MH091147NIMH NIH HHS R21 MH086805
6 · The paper itself

Abstract

When presented with a light cue followed by food, some rats simply approach the foodcup (Nonorienters), while others first orient to the light in addition to displaying the food-cup approach behavior (Orienters). Cue-directed orienting may reflect enhanced attentional and/or emotional processing of the cue, suggesting divergent natures of cue-information processing in Orienters and Nonorienters. The current studies investigate how differences in cue processing might manifest in appetitive memory retrieval and updating using a paradigm developed to persistently attenuate fear responses (Retrieval-extinction paradigm; Monfils et al., 2009). First, we examined whether the retrieval-extinction paradigm could attenuate appetitive responses in Orienters and Nonorienters. Next, we investigated if the appetitive memory could be updated using reversal learning (fear conditioning) during the reconsolidation window (as opposed to repeated unreinforced trials, i.e., extinction). Both extinction and new fear learning given within the reconsolidation window were effective at persistently updating the initial appetitive memory in the Orienters, but not the Nonorienters. Since conditioned orienting is mediated by the amygdala central nucleus (CeA), our final experiment examined the CeA's role in the retrieval-extinction process. Bilateral CeA lesions interfered with the retrieval-extinction paradigm-did not prevent spontaneous recovery of food-cup approach. Together, our studies demonstrate the critical role of conditioned orienting behavior and the CeA in updating appetitive memory during the reconsolidation window.

Indexed as

appetitive learningcentral amygdalaconditioned orientingextinctionfear learning

Identifiers

PMID24367304
PMCPMC3856395

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.