ArticlePLoS genetics2013
Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.Journal of virology · 2017Trial
- Pathogen detection in acellular cerebrospinal fluid: diagnostic insights from a pediatric cohort in Colombia.Microbiology spectrum · 2026Observational
- Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA.Science advances · 2026Article
- Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.Journal of virology · 2025Article
- Article
- Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis.Frontiers in immunology · 2025Article
- Article
- Article
- Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa.Molecular biology and evolution · 2021Article
- Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in medicine · 2021Article
- The antiviral immune forces awaken in the cancer wars.PLoS pathogens · 2020Article
- Endogenization and excision of human herpesvirus 6 in human genomes.PLoS genetics · 2020Article
- Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations.Virus evolution · 2020Article
- Chlamydia trachomatis and human herpesvirus 6 infections in ovarian cancer-Casual or causal?PLoS pathogens · 2019Review
- Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Journal of translational medicine · 2018Review
- Article
- Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains.Journal of virology · 2018Article
- HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation.NPJ genomic medicine · 2018Article
- Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.Frontiers in microbiology · 2018Article
- Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.Journal of virology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 95% of the human population is infected with human herpesvirus-6 (HHV-6) during early childhood and maintains latent HHV-6 genomes either in an extra-chromosomal form or as a chromosomally integrated HHV-6 (ciHHV-6). In addition, approximately 1% of humans are born with an inheritable form of ciHHV-6 integrated into the telomeres of chromosomes. Immunosuppression and stress conditions can reactivate latent HHV-6 replication, which is associated with clinical complications and even death. We have previously shown that Chlamydia trachomatis infection reactivates ciHHV-6 and induces the formation of extra-chromosomal viral DNA in ciHHV-6 cells. Here, we propose a model and provide experimental evidence for the mechanism of ciHHV-6 reactivation. Infection with Chlamydia induced a transient shortening of telomeric ends, which subsequently led to increased telomeric circle (t-circle) formation and incomplete reconstitution of circular viral genomes containing single viral direct repeat (DR). Correspondingly, short t-circles containing parts of the HHV-6 DR were detected in cells from individuals with genetically inherited ciHHV-6. Furthermore, telomere shortening induced in the absence of Chlamydia infection also caused circularization of ciHHV-6, supporting a t-circle based mechanism for ciHHV-6 reactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.