ArticlePLoS pathogens2013
A human torque teno virus encodes a microRNA that inhibits interferon signaling.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 87 citations in OpenAlex.
- Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation.PloS one · 2015Trial
- Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses.PLoS pathogens · 2025Article
- Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability.Viruses · 2024Article
- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
- Article
- Phylogenetic analysis of torque teno virus in Romania: possible evidence of distinct geographical distribution.Archives of virology · 2022Article
- Association of post-transplantation anellovirus viral load with kidney transplant rejection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- Plasma Torquetenovirus (TTV) microRNAs and severity of COVID-19.Virology journal · 2022Article
- Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases.Microorganisms · 2021Review
- Retraction: A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling.PLoS pathogens · 2021Article
- Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.NPJ genomic medicine · 2021Article
- New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets.Pathogens (Basel, Switzerland) · 2020Review
- Human anelloviruses: diverse, omnipresent and commensal members of the virome.FEMS microbiology reviews · 2020Review
- Torque teno virus in liver diseases: On the way towards unity of view.World journal of gastroenterology · 2020Review
- Article
- Anellovirus Dynamics Are Associated With Primary Graft Dysfunction in Lung Transplantation.Transplantation direct · 2020Article
- Molecular Epidemiology of Anellovirus Infection in Children's Urine: A Cross-sectional Study.Advanced biomedical research · 2020Article
- Viral MicroRNAs: Interfering the Interferon Signaling.Current pharmaceutical design · 2020Review
- The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.PLoS pathogens · 2019Article
- Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples.Virology journal · 2018Article
Corrections and comments
- Retraction · 2021-06-01Error in Methods · Results Not Reproducible · Unreliable Data · Unreliable Image · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Torque teno viruses (TTVs) are a group of viruses with small, circular DNA genomes. Members of this family are thought to ubiquitously infect humans, although causal disease associations are currently lacking. At present, there is no understanding of how infection with this diverse group of viruses is so prevalent. Using a combined computational and synthetic approach, we predict and identify miRNA-coding regions in diverse human TTVs and provide evidence for TTV miRNA production in vivo. The TTV miRNAs are transcribed by RNA polymerase II, processed by Drosha and Dicer, and are active in RISC. A TTV mutant defective for miRNA production replicates as well as wild type virus genome; demonstrating that the TTV miRNA is dispensable for genome replication in a cell culture model. We demonstrate that a recombinant TTV genome is capable of expressing an exogenous miRNA, indicating the potential utility of TTV as a small RNA vector. Gene expression profiling of host cells identifies N-myc (and STAT) interactor (NMI) as a target of a TTV miRNA. NMI transcripts are directly regulated through a binding site in the 3'UTR. SiRNA knockdown of NMI contributes to a decreased response to interferon signaling. Consistent with this, we show that a TTV miRNA mediates a decreased response to IFN and increased cellular proliferation in the presence of IFN. Thus, we add Annelloviridae to the growing list of virus families that encode miRNAs, and suggest that miRNA-mediated immune evasion can contribute to the pervasiveness associated with some of these viruses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.