ArticleTheScientificWorldJournal2013
Goblet cells and mucin related gene expression in mice infected with Eimeria papillata.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Mixed Eimeria infections disrupt tight junctions and microbial homeostasis to compromise the intestinal mucosal barrier in rabbits: partial protection by Lactiplantibacillus plantarum supplementation.BMC veterinary research · 2026Article
- Exploring the interplay betweenThe veterinary quarterly · 2025Review
- Down-regulation of colon mucin production induced byFrontiers in parasitology · 2025Article
- Article
- Alterations in the jejunal microbiota and fecal metabolite profiles of rabbits infected with Eimeria intestinalis.Parasites & vectors · 2022Article
- Coccidia-Microbiota Interactions and Their Effects on the Host.Frontiers in cellular and infection microbiology · 2021Review
- The impact of exogenous dietary nucleotides in amelioratingVeterinary and animal science · 2020Article
- Influence ofFrontiers in veterinary science · 2020Article
- Dietary supplementation with free methionine or methionine dipeptide improves environment intestinal of broilers challenged with Eimeria spp.Journal of animal science · 2019Article
- Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens.Probiotics and antimicrobial proteins · 2019Article
- Basal and Infectious Enteritis in Broilers Under the I See Inside Methodology: A Chronological Evaluation.Frontiers in veterinary science · 2019Article
- Berberine improves the intestinal antioxidant status of laboratory mice,Saudi journal of biological sciences · 2017Article
- Review
- Beneficial effect of Punica granatum peel extract on murine malaria-induced spleen injury.BMC complementary and alternative medicine · 2016Article
- The potential role of Punica granatum treatment on murine malaria-induced hepatic injury and oxidative stress.Parasitology research · 2016Article
- Sex-determined susceptibility and differential MUC2 mRNA expression during the course of murine intestinal eimeriosis.Parasitology research · 2015Article
- Identification of Potential Biomarkers for Gut Barrier Failure in Broiler Chickens.Frontiers in veterinary science · 2015Article
- Antioxidant and anti-inflammatory activities of pomegranate (Punica granatum) on Eimeria papillata-induced infection in mice.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coccidiosis causes considerable economic loss in the poultry industry. The current study aimed to investigate the response of goblet cells as well as the induced tissue damage during Eimeria papillata infection. Mice were infected with sporulated E. papillata oocytes. On day 5 postinfection, the fecal output was determined. Also, the jejunum was prepared for the histological, histochemical, and molecular studies. Our results revealed that the intestinal coccidian infection with E. papillata induced a marked goblet cell hypoplasia and depleted mucus secretion. Also, the infection was able to alter the jejunal architecture and increased the apoptotic cells inside the villi. In addition, the real-time PCR results indicated that the inflammatory cytokines: TNF- α , iNOS, IFN- γ , and IL-1 β , were significantly upregulated. In contrast, the mRNA expression patterns of IL-6 in response to E. papillata infection did not differ significantly between control and infected mice. Moreover, the mRNA expression of TLR4 was significantly upregulated, whereas the expression of MUC2 is significantly downregulated upon infection. Further studies are required to understand the regulatory mechanisms of goblet cells related genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.