Evidence map›Paper›PMID 24367173›Full record

ArticleBreast cancer (Dove Medical Press)2011

Cancer biomarker HER-2/neu in breast cancer in Indian women.

Rajeev Singhai, Amit V Patil, Vinayak W Patil

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer (Dove Medical Press), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Rajeev SinghaiDepartment of Biochemistry, Grant Medical College and Sir J J Group of Hospitals, Mumbai, India.
Amit V PatilDepartment of General Surgery, Government Medical College, Miraj, Maharashtra, India.
Vinayak W PatilDepartment of Biochemistry, Grant Medical College and Sir J J Group of Hospitals, Mumbai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIM AND

objectivesIn Indian women with breast cancer, the HER-2/neu gene is amplified in 30% of cases. Elevated serum HER-2/neu levels have been shown to be associated with a poor clinical prognosis and decreased survival in early stage breast cancer patients, and testing for this may help to manage the disease. The present study was therefore to estimate serum HER-2/neu levels in breast cancer patients and associate these with other prognostic factors. MATERIALS AND

methodsSerum HER-2/neu levels were studied in 207 patients with breast cancer, 15 with benign breast diseases, (BBD) and 175 age-matched healthy controls. Patients' age, menopausal status, node, and estrogen receptor (ER) and progesterone receptor (PgR) status were compared with serum HER-2/neu levels.

resultsSerum HER-2/neu overexpression was associated with age, disease stage and positive nodal status but not with menopausal status. Serum HER-2/neu levels were negatively correlated with hormone receptor positivity.

conclusionHER-2/neu serum tests should be done more frequently in Indian women with breast cancer, irrespective of their ER and PgR hormone receptor status. ELISA is a reliable and economical tool to assess the HER-2/neu status in tumors, when breast tissue samples are not available.

Indexed as

breast cancerERhormone receptorPgRserum HER-2/neu receptor assay

Identifiers

PMID24367173
PMCPMC3846717

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