Evidence map›Paper›PMID 24367128›Full record

ArticlePsychosomatic medicine2014

Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats.

E Alison Holman, Ana Guijarro, James Lim, Daniele Piomelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Cannabinoid CBNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
  8. Metabolite profiling in posttraumatic stress disorder.Journal of molecular psychiatry · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E Alison Holman *Program in Nursing Science, University of California, Irvine, California, 92697, USA (Dr. Holman); Department of Anatomy and Neurobiology, University of California, Irvine, 3216 A Gillespie Neuroscience Research Facility, Irvine, California, 92697, USA (Drs. Guijarro and Piomelli, Mr. Lim); Drug Discovery and Development, Italian Institute of Technology, via Morego 30, Genoa, Italy 16163 (Drs. Guijarro and Piomelli).
Ana Guijarro *Program in Nursing Science, University of California, Irvine, California, 92697, USA (Dr. Holman); Department of Anatomy and Neurobiology, University of California, Irvine, 3216 A Gillespie Neuroscience Research Facility, Irvine, California, 92697, USA (Drs. Guijarro and Piomelli, Mr. Lim); Drug Discovery and Development, Italian Institute of Technology, via Morego 30, Genoa, Italy 16163 (Drs. Guijarro and Piomelli).
James LimProgram in Nursing Science, University of California, Irvine, California, 92697, USA (Dr. Holman); Department of Anatomy and Neurobiology, University of California, Irvine, 3216 A Gillespie Neuroscience Research Facility, Irvine, California, 92697, USA (Drs. Guijarro and Piomelli, Mr. Lim); Drug Discovery and Development, Italian Institute of Technology, via Morego 30, Genoa, Italy 16163 (Drs. Guijarro and Piomelli).
Daniele PiomelliProgram in Nursing Science, University of California, Irvine, California, 92697, USA (Dr. Holman); Department of Anatomy and Neurobiology, University of California, Irvine, 3216 A Gillespie Neuroscience Research Facility, Irvine, California, 92697, USA (Drs. Guijarro and Piomelli, Mr. Lim); Drug Discovery and Development, Italian Institute of Technology, via Morego 30, Genoa, Italy 16163 (Drs. Guijarro and Piomelli).
Irvine Valley College · US

Funding

Role of oleoylethanolamide in the control of food intakeR01DK073955 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 2007 to 2010
$1.3M
Role of endocannabinoid signaling in stress-coping behaviorRL1AA017538 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 2007 to 2011
$1.1M
Intramural NIH HHSNIAAA NIH HHS RL1 AA017538NIDDK NIH HHS R01 DK073955
6 · The paper itself

Abstract

objectiveTrauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis and stress-related cardiovascular function. We examine stress-related ECS activity and its association with cardiovascular biochemistry/function after AS.

methodsRodents (n = 8-16/group) were exposed to predator odor or saline; elevated plus maze, blood pressure, serum and cardiac ECS markers, and lipid metabolism were assessed 24 hours and 2 weeks postexposure.

resultsAt 24 hours, the predator odor group demonstrated anxiety-like behavior and had a) elevated serum markers of cardiac failure/damage (brain natriuretic peptide: 275.1 versus 234.6, p = .007; troponin I: 1.50 versus 0.78, p = .076), lipogenesis (triacylglycerols: 123.5 versus 85.93, p = .018), and inflammation (stearoyl delta-9 desaturase activity: 0.21 versus 0.07, p < .001); b) decreased cardiac 2-arachidonoyl-sn-glycerol (29.90 versus 65.95, p < .001), oleoylethanolamide (114.3 versus 125.4, p = .047), and palmitoylethanolamide (72.96 versus 82.87, p = .008); and c) increased cardiac inflammation (interleukin [IL]-1β/IL-6 ratio: 19.79 versus 13.57, p = .038; tumor necrosis factor α/IL-6 ratio: 1.73 versus 1.03, p = .019) and oxidative stress (thiobarbituric acid reactive substances: 7.81 versus 7.05, p = .022), which were associated with cardiac steatosis (higher triacylglycerol: 1.09 versus 0.72, p < .001). Cardiac lipogenesis persisted, and elevated blood pressure emerged 2 weeks postexposure.

conclusionsAcute psychological stress elicits ECS-related cardiac responses associated with persistent, potentially pathological changes in rat cardiovascular biochemistry/function.

Indexed as

AnimalsAnxietyBehavior, AnimalBiomarkersEndocannabinoidsHeart DiseasesInflammationLipogenesisMaleRandom AllocationRatsRats, Sprague-DawleyStress Disorders, Traumatic, AcuteTime FactorsBiomarkersEndocannabinoidsacute stresscardiovascular statusendocannabinoidsinflammationlipogenesistriacylglycerols

Identifiers

PMID24367128
PMCPMC3988664
OpenAlexW2088070078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.