ArticlePsychosomatic medicine2014
Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder.
Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pooled it
- Stress does not affect ghrelin secretion in obese and normal weight women.Eating and weight disorders : EWD · 2017Trial
- Hunger on the Three-Factor Eating Questionnaire Is Associated With Increased Ad Libitum Energy Intake in Different Conditions.Obesity (Silver Spring, Md.) · 2026Article
- Affective factors predicting Binge Eating Disorder: The role of emotion regulation, impulsivity, and cognitive distortions.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2025Article
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Review
- Morning and afternoon appetite and gut hormone responses to meal and stress challenges in obese individuals with and without binge eating disorder.International journal of obesity (2005) · 2018Article
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Ghrelin stimulation by hypothalamic-pituitary-adrenal axis activation depends on increasing cortisol levels.Endocrine connections · 2017Article
- Stress, overeating, and obesity: Insights from human studies and preclinical models.Neuroscience and biobehavioral reviews · 2017Review
- Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.Journal of neurogastroenterology and motility · 2017Review
- Hormonal Factors and Disturbances in Eating Disorders.Current psychiatry reports · 2016Review
- Acute Stressors Reduce Neural Inhibition to Food Cues and Increase Eating Among Binge Eating Disorder Symptomatic Women.Frontiers in behavioral neuroscience · 2016Article
- Stress-induced release of GUT peptides in young women classified as restrained or unrestrained eaters.Eating and weight disorders : EWD · 2015Article
- Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems.Psychological medicine · 2015Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGhrelin, a peptide hormone secreted mainly by the stomach, increases appetite and food intake. Surprisingly, ghrelin levels are lower in obese individuals with binge eating disorder (BED) than in obese non-BED individuals. Acute psychological stress has been shown to raise ghrelin levels in animals and humans. Our aim was to assess ghrelin levels after a cold pressor test (CPT) in women with BED. We also examined the relationship between the cortisol stress response and changes in ghrelin levels.
methodsTwenty-one obese (mean [standard deviation] body mass index = 34.9 [5.8] kg/m(2)) women (10 non-BED, 11 BED) underwent the CPT, hand submerged in ice water for 2 minutes. Blood samples were drawn for 70 minutes and assayed for ghrelin and cortisol.
resultsThere were no differences between the groups in ghrelin levels at baseline (-10 minutes). Ghrelin rose significantly after the CPT (F = 2.4, p = .024) peaking at 19 minutes before declining (F = 17.9, p < .001), but there were no differences between the BED and non-BED groups. Area under the curve for ghrelin was not related to ratings of pain, stress, hunger, or desire to eat after CPT. In addition, there were no observed relationships between the area under the curves for ghrelin or cortisol after stress.
conclusionsAlthough there were no differences between BED groups, there was a significant rise in ghrelin in obese humans after a stressor, consistent with other recent reports suggesting a stress-related role for ghrelin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.