Trial reportPsychosomatic medicine2014
Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial.
Trial report in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01561105 (This Was a Five-year Seven-site Trial to Study the Cost-effectiveness of a Population Based Disease Management Program for Late Life Depression in Primary Care.), which is not on this map. Cited by 59 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
This Was a Five-year Seven-site Trial to Study the Cost-effectiveness of a Population Based Disease Management Program for Late Life Depression in Primary Care.
Who cites it
59 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Collaborative care approaches for people with severe mental illness.The Cochrane database of systematic reviews · 2024Pooled it
- Trends, challenges, and priorities for shared decision making in mental health: The first umbrella review.The International journal of social psychiatry · 2023Pooled it
- Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Pooled it
- Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data: A Scoping Review and Analysis.JAMA network open · 2018Pooled it
- Shared Decision-Making: a Systematic Review Focusing on Mood Disorders.Current psychiatry reports · 2018Pooled it
- [Spanish Adaptation of the 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice].Revista espanola de salud publica · 2016Guideline
- Guideline
- Pooled it
- Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial.Brain, behavior, and immunity · 2023Trial
- Intensive psychotherapy and case management for Karen refugees with major depression in primary care: a pragmatic randomized control trial.BMC family practice · 2020Trial
- A Cluster Randomized Trial of Primary Care Practice Redesign to Integrate Behavioral Health for Those Who Need It Most: Patients With Multiple Chronic Conditions.Annals of family medicineTrial
- Impact of collaborative care model treatment for depression and anxiety on cardiovascular risk factors using electronic health record data.Journal of affective disorders · 2025Article
- Impact of Depressive Symptom Severity on Stroke Risk in a US Cohort of People with HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Linking cardiometabolic multimorbidity to depressive symptoms in the oldest-old: results from a cross-sectional study in Germany.BMC public health · 2025Article
- Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care.JAMA health forum · 2025Article
- Behavioral Medicine Can Tackle Cardiovascular Disease Risk and Burden: A Call for New Priorities.Policy insights from the behavioral and brain sciences · 2025Article
- Mental disorders after myocardial infarction: potential mediator role for chemokines in heart-brain interaction?Journal of geriatric cardiology : JGC · 2024Article
- Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors.JACC. Advances · 2024Article
- Multilevel perspectives on the implementation of the collaborative care model for depression and anxiety in primary care.BMC psychiatry · 2024Article
- Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveAlthough depression is a risk and prognostic factor for cardiovascular disease (CVD), depression trials involving cardiac patients have not observed the anticipated cardiovascular benefits. To test our hypothesis that depression treatment delivered before clinical CVD onset reduces risk of CVD events, we conducted an 8-year follow-up study of the Indiana sites of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) randomized controlled trial.
methodsParticipants were 235 primary care patients 60 years or older with major depression or dysthymia who were randomized to a 12-month collaborative care program involving antidepressants and psychotherapy (85 without and 35 with baseline CVD) or usual care (83 without and 32 with baseline CVD). Hard CVD events (fatal/nonfatal) were identified using electronic medical record and Medicare/Medicaid data.
resultsA total of 119 patients (51%) had a hard CVD event. As hypothesized, the treatment × baseline CVD interaction was significant (p = .021). IMPACT patients without baseline CVD had a 48% lower risk of an event than did usual care patients (28% versus 47%, hazard ratio = 0.52, 95% confidence interval = 0.31-0.86). The number needed to treat to prevent one event for 5 years was 6.1. The likelihood of an event did not differ between IMPACT and usual care patients with baseline CVD (86% versus 81%, hazard ratio = 1.19, 95% confidence interval, 0.70-2.03).
conclusionsCollaborative depression care delivered before CVD onset halved the excess risk of hard CVD events among older, depressed patients. Our findings raise the possibility that the IMPACT intervention could be used as a CVD primary prevention strategy.
trial registrationclinicaltrials.gov Identifier: NCT01561105.
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