ArticleProceedings of the National Academy of Sciences of the United States of America2014
Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed.
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A scalable hippocampal code for flexible interval timing through persistent activity.bioRxiv : the preprint server for biology · 2026Article
- Article
- A neuronal correlate for time interval estimation in the crow's telencephalon.Nature communications · 2025Article
- Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Contextual neural dynamics during time perception in the primate ventral premotor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.eLife · 2024Article
- Mild focal cooling selectively impacts computations in dendritic trees.bioRxiv : the preprint server for biology · 2024Article
- Ramping cells in the rodent medial prefrontal cortex encode time to past and future events via real Laplace transform.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Surfacing of Latent Time Memories Supports the Representational Basis of Timing Behavior in Mice.Animal cognition · 2024Article
- Temporal scaling of motor cortical dynamics reveals hierarchical control of vocal production.Nature neuroscience · 2024Article
- Ramping cells in rodent mPFC encode time to past and future events via real Laplace transform.bioRxiv : the preprint server for biology · 2024Article
- Diverse Time Encoding Strategies Within the Medial Premotor Areas of the Primate.Advances in experimental medicine and biology · 2024Review
- Temporal Information Processing in the Cerebellum and Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Using temperature to analyze the neural basis of a time-based decision.Nature neuroscience · 2023Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Neural dynamics in the rodent motor cortex enables flexible control of vocal timing.bioRxiv : the preprint server for biology · 2023Article
- Temporal encoding: Relative and absolute representations of time guide behavior.Journal of experimental psychology. Animal learning and cognition · 2023Article
- Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.Frontiers in systems neuroscience · 2023Review
32 more citing papers are in PubMed but not listed here.
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Perception of time interval on the order of seconds is an essential component of cognition, but the underlying neural mechanism remains largely unknown. In rats trained to estimate time intervals, we found that many neurons in the medial prefrontal cortex (PFC) exhibited sustained spiking activity with diverse temporal profiles of firing-rate modulation during the time-estimation period. Interestingly, in tasks involving different intervals, each neuron exhibited firing-rate modulation with the same profile that was temporally scaled by a factor linearly proportional to the instructed intervals. The behavioral variability across trials within each task also correlated with the intertrial variability of the temporal scaling factor. Local cooling of the medial PFC, which affects neural circuit dynamics, significantly delayed behavioral responses. Thus, PFC neuronal activity contributes to time perception, and temporally scalable firing-rate modulation may reflect a general mechanism for neural representation of interval timing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.