ArticleThe Journal of infectious diseases2014
Community circulation patterns of oral polio vaccine serotypes 1, 2, and 3 after Mexican national immunization weeks.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Characterization of Household and Community Shedding and Transmission of Oral Polio Vaccine in Mexican Communities With Varying Vaccination Coverage.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Protocol Paper: Oral Poliovirus Vaccine Transmissibility in Communities After Cessation of Routine Oral Poliovirus Vaccine Immunization.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Mucosal immunity to poliovirus.Mucosal immunology · 2022Review
- Validation of the bag-mediated filtration system for environmental surveillance of poliovirus in Nairobi, Kenya.Journal of applied microbiology · 2021Article
- Human IgA Monoclonal Antibodies That Neutralize Poliovirus, Produced by Hybridomas and Recombinant Expression.Antibodies (Basel, Switzerland) · 2020Article
- Vaccination againstInfection and immunity · 2019Article
- Deep sequencing prompts the modification of a real-time RT-PCR for the serotype-specific detection of polioviruses.Journal of virological methods · 2019Article
- The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda.Virology journal · 2018Article
- Monitoring and Validation of the Global Replacement of tOPV with bOPV, April-May 2016.The Journal of infectious diseases · 2017Article
- Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing.Journal of clinical microbiology · 2017Article
- Observational
- Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?Virus evolution · 2015Article
- Challenges Facing Successful Scaling Up of Effective Screening for Cardiovascular Disease by Community Health Workers in Mexico and South Africa: Policy Implications.Health systems and policy researchArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWith wild poliovirus nearing eradication, preventing circulating vaccine-derived poliovirus (cVDPV) by understanding oral polio vaccine (OPV) community circulation is increasingly important. Mexico, where OPV is given only during biannual national immunization weeks (NIWs) but where children receive inactivated polio vaccine (IPV) as part of their primary regimen, provides a natural setting to study OPV community circulation.
methodsIn total, 216 children and household contacts in Veracruz, Mexico, were enrolled, and monthly stool samples and questionnaires collected for 1 year; 2501 stool samples underwent RNA extraction, reverse transcription, and real-time polymerase chain reaction (PCR) to detect OPV serotypes 1, 2, and 3.
resultsOPV was detected up to 7 months after an NIW, but not at 8 months. In total, 35% of samples collected from children vaccinated the prior month, but only 4% of other samples, contained OPV. Although each serotype was detected in similar proportions among OPV strains shed as a result of direct vaccination, 87% of OPV acquired through community spread was serotype 2 (P < .0001).
conclusionsSerotype 2 circulates longer and is transmitted more readily than serotypes 1 or 3 after NIWs in a Mexican community primarily vaccinated with IPV. This may be part of the reason why most isolated cVDPV has been serotype 2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.