ArticleAntimicrobial agents and chemotherapy2014
In vitro synergistic effect of amphotericin B and allicin on Leishmania donovani and L. infantum.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Mini-review: The health benefits and applications of allicin.Frontiers in pharmacology · 2025Review
- An update onParasite epidemiology and control · 2024Review
- Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales.International journal of molecular sciences · 2023Article
- Article
- Synergistic Anti-Leishmanial Activities of Morphine and Imiquimod onJournal of arthropod-borne diseases · 2021Article
- Review: antimicrobial properties of allicin used alone or in combination with other medications.Folia microbiologica · 2020Review
- Antileishmanial Activity and Synergistic Effects of Amphotericin B Deoxycholate with Allicin and Andrographolide againstPathogens (Basel, Switzerland) · 2020Article
- Article
- Glycyrrhizic acid attenuates growth of Leishmania donovani by depleting ergosterol levels.Experimental parasitology · 2017Article
- Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations.PloS one · 2017Article
- Article
- Antileishmanial effect of mevastatin is due to interference with sterol metabolism.Parasitology research · 2015Article
- Resveratrol is active against Leishmania amazonensis: in vitro effect of its association with Amphotericin B.Antimicrobial agents and chemotherapy · 2014Article
- Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani.Parasitology research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current monotherapy against visceral leishmaniasis has serious side effects, and resistant Leishmania strains have been identified. Amphotericin B (AmB) has shown an extraordinary antileishmanial efficacy without emergence of resistance; however, toxicity has limited its general use. Results obtained showed, using a fixed-ratio analysis, that the combination of diallyl thiosulfinate (allicin) and AmB ranged from moderately synergic to synergic at low concentrations (0.07 μM AmB plus 35.45 μM allicin induced 95% growth inhibition). None of the treatments, alone or in combination, had noticeable adverse effects on macrophages (M) in the concentration range examined (allicin, 0.5, 1, 5 and 10 μM; AmB, 0.05, 0.075, and 0.1 μM). Allicin, AmB, or the combination did not affect the infection rate (percentage of infected M) of Leishmania. Allicin enhanced the activity of AmB on intracellular amastigotes of Leishmania donovani and L. infantum (ca. 45% reduction of amastigote burden with 0.05 μM AmB plus 10 μM allicin); this represented nearly a 2-fold reduction in the 50% inhibitory concentration (IC50) of the antibiotic added alone. Results point toward the possible utility of testing this combination in vivo to reduce the toxicity associated with monotherapy with AmB.
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