ArticleAntimicrobial agents and chemotherapy2014
Phylogenetic relationships matter: antifungal susceptibility among clinically relevant yeasts.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- An update on clinically relevant, rare, and emergingClinical microbiology reviews · 2025Review
- The development of single-domain VHH nanobodies that target theMicrobiology spectrum · 2024Article
- Phylogenomic analysis of thePersoonia · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion.Journal of clinical microbiology · 2024Article
- Rationalisation of Antifungal Properties of α-Helical Pore-Forming Peptide, Mastoparan B.Molecules (Basel, Switzerland) · 2022Article
- High incidence of azole resistance amongCurrent medical mycology · 2021Article
- Central Nervous System Mold Infections in Children with Hematological Malignancies: Advances in Diagnosis and Treatment.Journal of fungi (Basel, Switzerland) · 2021Review
- Recent trends in molecular diagnostics of yeast infections: from PCR to NGS.FEMS microbiology reviews · 2019Review
- Hand dermatitis withPostepy dermatologii i alergologii · 2018Article
- Rapid Detection and Identification of Candidemia by Direct Blood Culturing on Solid Medium by Use of Lysis-Centrifugation Method Combined with Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS).Journal of clinical microbiology · 2017Article
- Disseminated yeastThe Canadian veterinary journal = La revue veterinaire canadienne · 2016Article
- Parallel and cross-resistances of clinical yeast isolates determined by susceptibility pattern analysis.GMS infectious diseases · 2016Article
- Name changes in medically important fungi and their implications for clinical practice.Journal of clinical microbiology · 2015Article
- In vitro activities of amphotericin B deoxycholate and liposomal amphotericin B against 604 clinical yeast isolates.Journal of medical microbiology · 2014Article
- Evolutionary Perspectives on Human Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
- Epidemiology and changes in patient-related factors from 1997 to 2009 in clinical yeast isolates related to dermatology, gynaecology, and paediatrics.International journal of microbiology · 2013Article
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7 authors.
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Abstract
The objective of this study was 2-fold: to evaluate whether phylogenetically closely related yeasts share common antifungal susceptibility profiles (ASPs) and whether these ASPs can be predicted from phylogeny. To address this question, 9,627 yeast strains were collected and tested for their antifungal susceptibility. Isolates were reidentified by considering recent changes in taxonomy and nomenclature. A phylogenetic (PHYLO) code based on the results of multilocus sequence analyses (large-subunit rRNA, small-subunit rRNA, translation elongation factor 1α, RNA polymerase II subunits 1 and 2) and the classification of the cellular neutral sugar composition of coenzyme Q and 18S ribosomal DNA was created to group related yeasts into PHYLO groups. The ASPs were determined for fluconazole, itraconazole, and voriconazole in each PHYLO group. The majority (95%) of the yeast strains were Ascomycetes. After reclassification, a total of 23 genera and 54 species were identified, resulting in an increase of 64% of genera and a decrease of 5% of species compared with the initial identification. These taxa were assigned to 17 distinct PHYLO groups (Ascomycota, n=13; Basidiomycota, n=4). ASPs for azoles were similar among members of the same PHYLO group and different between the various PHYLO groups. Yeast phylogeny may be an additional tool to significantly enhance the assessment of MIC values and to predict antifungal susceptibility, thereby more rapidly initiating appropriate patient management.
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