ArticleMolecular biology reports2014
Role of 677C→T polymorphism a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Medicine · 2020Pooled it
- Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis.Medicine · 2019Pooled it
- Role of genetic mutations in folate-related enzyme genes on Male Infertility.Scientific reports · 2015Pooled it
- MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.PloS one · 2015Pooled it
- Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect.BioMed research international · 2017Trial
- Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis andToxicology reports · 2025Review
- Effects of Gender Differences inInternational journal of genomics · 2025Article
- Correlation of MTHFR C677T Polymorphism with Male Infertility among Indian Population: Case-Control Study.Journal of pharmacy & bioallied sciences · 2024Article
- MTHFR Gene-Polymorphism and Infertile Men in Indian Population: A Systematic Literature Review.Cureus · 2022Review
- Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population.Indian journal of clinical biochemistry : IJCB · 2017Article
- Retrospective case-control study of correlation between MTHFR gene and OSCC risk in North India.Clinical oral investigations · 2017Article
- Association ofInternational journal of clinical and experimental pathology · 2017Article
- Association of theBalkan journal of medical genetics : BJMG · 2016Article
- Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.Journal of assisted reproduction and genetics · 2015Article
- Strong association ofAsian journal of andrologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Failure or severe difficulty in conceiving a child is surprisingly common, worldwide problem. Half of these cases are due to male factors with defects in sperm (1 in 15 men) being the single most common cause. Also about 60-75 % of male infertility cases are idiopathic, since the molecular mechanisms underlying the defects remain unknown. DNA methylation is crucial for spermatogenesis and high methylenetetrahydrofolate reductase (MTHFR) activity in adult testis than other organs in mouse, signifies its critical role in spermatogenesis. According to recent findings there is a correlation of epigenetic regulation of several imprinted genes with disturbed spermatogenesis and fertility. Consequently any change in the MTHFR gene sequence can modify the spermatogenesis including transmission of infertility to the carriers. The aim of the study is to analyze the distribution of the single nucleotide polymorphism C677T in the MTHFR gene in 637 North Indian infertile patients and 364 fertile North Indian men as controls by using PCR-RFLP technique and Chi Square test for statistical analysis. The average MTHFR 677CC, 677CT, 677TT genotype frequencies of total infertile men were 70.17, 24.17, 5.65 % in infertile men and 75.27, 21.7, 2.74 % in controls, respectively. The average frequency of the MTHFR 677T allele was 17.73 % in infertile men as compared to 13.59 % in controls. The statistical difference was significant. Disease risk was found 2.27-folds increased in patients who were carrying T allele. We found an association of C677T polymorphism with male infertility and that it may be a genetic risk factor for male infertility in North Indian population.
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