ReviewClinical reviews in allergy & immunology2014
NK cell trafficking in health and autoimmunity:a comprehensive review.
Review in Clinical reviews in allergy & immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Trial
- Natural Killer Cells in Graves' Disease: Increased Frequency but Impaired Degranulation Ability Compared to Healthy Controls.International journal of molecular sciences · 2025Article
- Recent advances in tumor immunotherapy based on NK cells.Frontiers in immunology · 2025Review
- Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications.Frontiers in immunology · 2025Review
- NK cell-based immunotherapy strategies for myeloid leukemia.Frontiers in immunology · 2025Review
- Single-cell adhesive profiling in an optofluidic device elucidates CD8Cell reports methods · 2024Article
- Exploiting innate immunity for cancer immunotherapy.Molecular cancer · 2023Review
- Metformin promotes antitumor activity of NK cells via overexpression of miRNA-150 and miRNA-155.American journal of translational research · 2023Article
- Natural killer cell homing and trafficking in tissues and tumors: from biology to application.Signal transduction and targeted therapy · 2022Review
- Chimeric antigen receptor (CAR) natural killer (NK)-cell therapy: leveraging the power of innate immunity.British journal of haematology · 2021Review
- Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.Mediators of inflammation · 2020Article
- Human Gut-Associated Natural Killer Cells in Health and Disease.Frontiers in immunology · 2019Review
- Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii.Immunology · 2018Article
- Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges.British journal of pharmacology · 2017Review
- Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Role of Integrin Expressing Cells in Modulating Disease Susceptibility and Progression (January 2016).International trends in immunity · 2016Article
- The negative NK cell maturation checkpoint Foxo1.Oncotarget · 2015Article
- Potential Use of Natural Killer Cell Transfer Therapy in the Perioperative Period to Improve Oncologic Outcomes.Scientifica · 2015Review
- Alteration of regulatory T cells in type 1 diabetes mellitus: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells represent an important subpopulation of lymphocytes that are distributed throughout the body. The development of NK cells primarily occurs in the bone marrow during adult life, involving several putative intermediate stages that finally result in functional maturation. At steady state, NK cell egress from the bone marrow to various peripheral areas is controlled by a network of adhesion molecules, including integrins, selectins, and chemokine receptors and their corresponding ligands. NK cells at different developmental stages express distinct repertoire of adhesion molecules and can therefore be recruited to different sites of the body, including lymphoid and non-lymphoid tissues, and NK cells undergo further differentiation driven by local microenvironmental signals, resulting in unique tissue-specific NK cells. Through their abilities of cytotoxicity and cytokine production, NK cells not only play key roles in the innate immune system, but also participate in shaping adaptive immune responses. On the basis of their heterogeneity in phenotype, function, and tissue distribution, NK cells can be further subdivided into distinct subsets. Under pathological conditions, such as in autoimmune, inflammatory, and infectious diseases, as local microenvironment changes, NK cell subsets would redistribute between tissues and organs and rapidly accumulate at the local pathological sites to exert their effector functions. Here, we describe the development and tissue distribution of NK cell subsets in mice and humans. We focus on the trafficking of NK cell subsets within the bone marrow and emigration into periphery at steady state, and molecular mechanisms involved in their trafficking in autoimmune diseases.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.