ArticlePediatric research2014
Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant.
Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03786497 (Protecting Brains and Saving Futures - the PBSF Protocol), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protecting Brains and Saving Futures - the PBSF Protocol: a Prospective Multicenter and Observational Study on the Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil.
Who cites it
32 citing papers in PubMed, 98 citations in OpenAlex.
- Long term electroencephalography in preterm neonates: Safety and quality of electrode types.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Trial
- The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury.Pediatric research · 2016Trial
- Defining neonatal status epilepticus: A scoping review from the ILAE neonatal task force.Epilepsia open · 2025Article
- Falls in oxygen saturations accompany electrographic seizures in term neonates: an observational study.Pediatric research · 2024Observational
- Neonatal Seizures in Low- and Middle-Income Countries: A Review of the Literature and Recommendations for the Management.Turkish archives of pediatrics · 2024Article
- Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023Review
- Neuromonitoring in neonatal critical care part I: neonatal encephalopathy and neonates with possible seizures.Pediatric research · 2023Review
- Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm.The Journal of pediatrics · 2023Article
- A practical approach toward interpretation of amplitude integrated electroencephalography in preterm infants.European journal of pediatrics · 2022Review
- Seizure burden in preterm infants and smaller brain volume at term-equivalent age.Pediatric research · 2022Article
- Article
- Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?Archives of disease in childhood. Fetal and neonatal edition · 2021Observational
- The visibility of the periventricular crossroads of pathways in preterm infants as a predictor of neurological outcome and occurrence of neonatal epileptic seizures.Croatian medical journal · 2021Article
- Neuromonitoring in Neonatal-Onset Epileptic Encephalopathies.Frontiers in neurology · 2021Review
- WU-NEAT: A clinically validated, open-source MATLAB toolbox for limited-channel neonatal EEG analysis.Computer methods and programs in biomedicine · 2020Article
- Seizures in Pre-term Infants Less than 29 Weeks: Incidence, Etiology, and Response to Treatment.Kansas journal of medicine · 2020Article
- Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.Vaccine · 2019Review
- Predictors of early vocabulary growth in children born preterm and full term: A study of processing speed and medical complications.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2019Article
- Amplitude-integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills.Acta paediatrica (Oslo, Norway : 1992) · 2019Article
- Symptomatic seizures in preterm newborns: a review on clinical features and prognosis.Italian journal of pediatrics · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies of very preterm (VPT) infants have shown a wide range of seizure prevalence and association with intraventricular hemorrhage (IVH), white matter injury (WMI), and death. However, the impact of seizures on neurodevelopment is not well known. We hypothesized that seizures in the first 3 d after VPT birth would be associated with increased radiographic brain injury and later neurodevelopmental risk.
methodsFor 72 h after birth, 95 VPT infants underwent amplitude-integrated electroencephalogram monitoring. High and low seizure burdens were related to radiographic brain injury, death in the neonatal period, and children's Bayley III (Bayley Scales of Infant Development) performance at 2 y corrected age in a subgroup of 59 infants.
resultsThe overall incidence of seizures in this sample was 48%. High seizure burden was associated with increased risk of IVH on day 1; IVH, WMI, and death on day 2; and high-grade IVH on day 3. The presence of seizures on any day was associated with decreased language performance at age 2, even after controlling for family social risk.
conclusionSeizures during the first 3 d after birth are common and are associated with an increased risk of IVH, WMI, and death. They were also associated with poorer early language development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.