ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2014
Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pharmacotherapies to prevent epidural fibrosis after laminectomy: a systematic review of in vitro and in vivo animal models.The spine journal : official journal of the North American Spine Society · 2023Pooled it
- Postoperative Epidural Fibrosis: Challenges and Opportunities - A Review.Spine surgery and related research · 2024Review
- Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in ratsTurkish journal of medical sciences · 2021Article
- Intra-articular injection of mitomycin C prevents progression of immobilization-induced arthrogenic contracture in the remobilized rat knee.Physiological research · 2020Article
- Article
- Prospective application of stem cells to prevent post-operative skeletal fibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2015Article
- Intra-articular adhesion reduction after knee surgery in rabbits by calcium channel blockers.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats.BMC musculoskeletal disorders · 2014Article
- EFFECT OF PLATELET-RICH PLASMA, FAT PAD AND DURAL MATRIX IN PREVENTING EPIDURAL FIBROSIS.Acta ortopedica brasileiraArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats.
methodsA controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. All rats were divided randomly into three groups according to the treatment method, with 20 in each group: (1) VP treatment group; (2) vehicle treatment group; and (3) sham group (laminectomy without treatment). All rats were killed 4 weeks post-laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density and inflammatory factors expressions were evaluated.
resultsThe histological evaluation showed less epidural scar adhesions in verapamil group than other two groups. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density and inflammatory factors expressions all suggested better results in verapamil group than other two groups.
conclusionTopical application of verapamil could inhibit fibroblasts proliferation and TGF-β1 and IL-6 expressions and prevent epidural scar adhesion in post-laminectomy rat model.
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