SynthesisBritish journal of cancer2014
Statin use is not associated with reduced risk of skin cancer: a meta-analysis.
Synthesis in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials.Drug design, development and therapy · 2019Pooled it
- Association Between Statin Use and Non-Melanoma Skin Cancer Risk: A Distributed Network Analysis of 11 Real-World Databases.Annals of dermatology · 2026Article
- Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation.Journal of clinical medicine · 2025Review
- Investigating potential anti-proliferative activity of different statins against five cancer cell lines.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Cardiovascular Immunotoxicity Associated with Immune Checkpoint Inhibitors in Metastatic Melanoma.Cancers · 2023Article
- Assessing the role of lipid-lowering therapy on multi-cancer prevention: A mendelian randomization study.Frontiers in pharmacology · 2023Article
- Review
- Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy.Frontiers in oncology · 2020Review
- Review
- Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.Scientific reports · 2018Article
- Statin use and risk of skin cancer.Journal of the American Academy of Dermatology · 2018Article
- Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies.Oncotarget · 2017Article
- Melanoma Chemoprevention: Current Status and Future Prospects.Photochemistry and photobiology · 2017Review
- Marketed drugs used for the management of hypercholesterolemia as anticancer armament.OncoTargets and therapy · 2017Review
- Repurposing of approved cardiovascular drugs.Journal of translational medicine · 2016Review
- Anti-proliferative and cytotoxic activity of rosuvastatin against melanoma cells.Postepy dermatologii i alergologii · 2016Article
- Relation of statin use with non-melanoma skin cancer: prospective results from the Women's Health Initiative.British journal of cancer · 2016Observational
- C-reactive protein as a marker of melanoma progression.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark.British journal of cancer · 2015Article
- Statins: do they have a potential role in cancer prevention and modifying cancer-related outcomes?Drugs · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is contradictory evidence about the association between statin and skin cancer.
methodsLiterature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated.
resultA total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19).
conclusionOur meta-analysis does not support a potential role of statin use in the prevention of skin cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.