ArticleInfection and immunity2014
Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Role of ClpX and MsrA/B in the Oxidative and Cell Wall Stress Response in Bacillus anthracis Sterne.MicrobiologyOpen · 2026Article
- Metabolic response of tellurite resistant Bacillus altitudinis strain 3W19 highlights the potential as a model organism for bioremediation.Scientific reports · 2025Article
- Genomic and metabolic characterization ofApplied and environmental microbiology · 2025Article
- Bacillus megaterium HgT21: a Promising Metal Multiresistant Plant Growth-Promoting Bacteria for Soil Biorestoration.Microbiology spectrum · 2022Article
- Potential of tellurite resistance in heterotrophic bacteria from mining environments.iScience · 2022Article
- Interactions between the Re-Emerging PathogenInternational journal of molecular sciences · 2022Review
- Emergence of K1 ST23 and K2 ST65 hypervirulentFrontiers in cellular and infection microbiology · 2022Article
- Identification of hypervirulentFrontiers in public health · 2022Article
- Genomic, Phenotypic, and Virulence Analysis ofInfection and immunity · 2019Article
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- Comparative Genomics ofFrontiers in microbiology · 2017Article
- Late-Exponential Gene Expression in codY-Deficient Bacillus anthracis in a Host-Like Environment.Current microbiology · 2016Article
- Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions.BMC genomics · 2016Article
- Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans.Memorias do Instituto Oswaldo Cruz · 2015Article
- Association of tellurite resistance with hypervirulent clonal groups of Klebsiella pneumoniae.Journal of clinical microbiology · 2015Article
- Role of Tellurite Resistance Operon in Filamentous Growth of Yersinia pestis in Macrophages.PloS one · 2015Article
- Identification of Pathogenicity-Associated Loci in Klebsiella pneumoniae from Hospitalized Patients.mSystemsArticle
- Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections.Pathogens and global healthReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Bacillus anthracis, the causative agent of anthrax, relies on multiple virulence factors to subvert the host immune defense. Using Caenorhabditis elegans as an infection model, we screened approximately 5,000 transposon mutants of B. anthracis Sterne for decreased virulence. One of the attenuated mutants resulted in loss of expression of yceG and yceH, the last two genes in a six-gene cluster of tellurite resistance genes. We generated an analogous insertional mutant to confirm the phenotype and characterize the role of yceGH in resistance to host defenses. Loss of yceGH rendered the mutants more sensitive to tellurite toxicity as well as to host defenses such as reactive oxygen species and the cathelicidin family of antimicrobial peptides. Additionally, we see decreased survival in mammalian models of infection, including human whole blood and in mice. We identify a novel role for the yceGH genes in B. anthracis Sterne virulence and suggest that C. elegans is a useful infection model to study anthrax pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.