Evidence map›Paper›PMID 24366234›Full record

ArticleThe American journal of gastroenterology2014

A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.

Peter H Dixon, Christopher A Wadsworth, Jennifer Chambers, Jennifer Donnelly, Sharon Cooley, Rebecca Buckley, Ramona Mannino, Sheba Jarvis, Argyro Syngelaki, Victoria Geenes and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025
    Review
  8. Article
  9. Article
  10. Hepatic immune regulation and sex disparities.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  11. Article
  12. Genetic issues in ICP.Obstetric medicine · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Nuclear Receptors in Pregnancy and Outcomes: Clinical Perspective.Advances in experimental medicine and biology · 2022
    Article
  17. Article
  18. Intrahepatic Cholestasis of Pregnancy.Geburtshilfe und Frauenheilkunde · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 4 countries.

Peter H Dixon1] Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK [2] Present address: Division of Women's Health, King's College London, London, UK.
Christopher A WadsworthHepatology and Gastroenterology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Jennifer ChambersMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Jennifer DonnellyThe Rotunda Hospital, Dublin, Ireland.
Sharon CooleyThe Rotunda Hospital, Dublin, Ireland.
Rebecca BuckleyMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Ramona ManninoMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Sheba JarvisMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Argyro SyngelakiHarris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Victoria GeenesMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Priyadarshini PaulMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Meera SothinathanMaternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK.
Ralf KubitzDepartment of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf, Düsseldorf, Germany.
Frank LammertDepartment of Medicine II, Saarland University Medical Centre, Homburg, Germany.
Rachel M TribeDivision of Women's Health, King's College London, London, UK.
Chin Lye Ch'ngDepartment of Gastroenterology, Singleton Hospital, Abertawe Bro Morgannwg University Health Board, Swansea, UK.
Hanns-Ulrich MarschallSahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Anna GlantzAntenatal Care, Gothenburg, Primärvårdskansliet, Hisings Backa, Sweden.
Shahid A KhanHepatology and Gastroenterology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Kypros NicolaidesHarris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
John Whittaker1] London School of Hygiene and Tropical Medicine, University of London, London, UK [2] Quantitative Sciences, GlaxoSmithKline, Stevenage, UK.
Michael GearyThe Rotunda Hospital, Dublin, Ireland.
Catherine Williamson1] Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Division of Surgery and Cancer, Imperial College London, London, UK [2] Present address: Division of Women's Health, King's College London, London, UK.
Imperial College London · GBRotunda Hospital · IEKing's College Hospital · GBGlaxoSmithKline (United Kingdom) · GBHeinrich Heine University Düsseldorf · DEKing's College London · GBSaarland University · DESingleton Hospital · GBUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIntrahepatic cholestasis of pregnancy (ICP) has a complex etiology with a significant genetic component. Heterozygous mutations of canalicular transporters occur in a subset of ICP cases and a population susceptibility allele (p.444A) has been identified in ABCB11. We sought to expand our knowledge of the detailed genetic contribution to ICP by investigation of common variation around candidate loci with biological plausibility for a role in ICP (ABCB4, ABCB11, ABCC2, ATP8B1, NR1H4, and FGF19).

methodsICP patients (n=563) of white western European origin and controls (n=642) were analyzed in a case-control design. Single-nucleotide polymorphism (SNP) markers (n=83) were selected from the HapMap data set (Tagger, Haploview 4.1 (build 22)). Genotyping was performed by allelic discrimination assay on a robotic platform. Following quality control, SNP data were analyzed by Armitage's trend test.

resultsCochran-Armitage trend testing identified six SNPs in ABCB11 together with six SNPs in ABCB4 that showed significant evidence of association. The minimum Bonferroni corrected P value for trend testing ABCB11 was 5.81×10(-4) (rs3815676) and for ABCB4 it was 4.6×10(-7)(rs2109505). Conditional analysis of the two clusters of association signals suggested a single signal in ABCB4 but evidence for two independent signals in ABCB11. To confirm these findings, a second study was performed in a further 227 cases, which confirmed and strengthened the original findings.

conclusionsOur analysis of a large cohort of ICP cases has identified a key role for common variation around the ABCB4 and ABCB11 loci, identified the core associations, and expanded our knowledge of ICP susceptibility.

Indexed as

ATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 11Case-Control StudiesCholestasis, IntrahepaticEuropeFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHeterozygoteHumansMultidrug Resistance-Associated Protein 2MutationPolymorphism, Single NucleotidePregnancyPregnancy ComplicationsABCB11 protein, humanABCC2 protein, humanATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 11Multidrug Resistance-Associated Protein 2multidrug resistance protein 3

Identifiers

PMID24366234
PMCPMC3887577
OpenAlexW2087652581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.