ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
The development of spatial behaviour and the hippocampal neural representation of space.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Continuous monitoring and machine vision reveals that developing gerbils exhibit structured social behaviors prior to the emergence of autonomy.PLoS biology · 2025Article
- Effects of cypermethrin exposure on learning and memory functions and anxiety-like behavior in rats.BMC pharmacology & toxicology · 2025Article
- Early and late place cells during postnatal development of the hippocampus.Nature communications · 2024Article
- Environment geometry alters subiculum boundary vector cell receptive fields in adulthood and early development.Nature communications · 2024Article
- Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit.Development (Cambridge, England) · 2024Article
- Septotemporal Variation of Information Processing in the Hippocampus of Fmr1 KO Rat.Developmental neuroscience · 2024Article
- Sharpening the blades of the dentate gyrus: how adult-born neurons differentially modulate diverse aspects of hippocampal learning and memory.The EMBO journal · 2023Review
- Article
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups.Scientific reports · 2022Article
- Article
- Extensive Structural Remodeling of the Axonal Arbors of Parvalbumin Basket Cells during Development in Mouse Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy.Brain, behavior, & immunity - health · 2020Article
- Postnatal Development of Functional Projections from Parasubiculum and Presubiculum to Medial Entorhinal Cortex in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Coordinated Emergence of Hippocampal Replay and Theta Sequences during Post-natal Development.Current biology : CB · 2019Article
- Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.Neuron · 2017Article
- Article
- Sensory feedback synchronizes motor and sensory neuronal networks in the neonatal rat spinal cord.Nature communications · 2016Article
- Place Cell Networks in Pre-weanling Rats Show Associative Memory Properties from the Onset of Exploratory Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The role of the hippocampal formation in spatial cognition is thought to be supported by distinct classes of neurons whose firing is tuned to an organism's position and orientation in space. In this article, we review recent research focused on how and when this neural representation of space emerges during development: each class of spatially tuned neurons appears at a different age, and matures at a different rate, but all the main spatial responses tested so far are present by three weeks of age in the rat. We also summarize the development of spatial behaviour in the rat, describing how active exploration of space emerges during the third week of life, the first evidence of learning in formal tests of hippocampus-dependent spatial cognition is observed in the fourth week, whereas fully adult-like spatial cognitive abilities require another few weeks to be achieved. We argue that the development of spatially tuned neurons needs to be considered within the context of the development of spatial behaviour in order to achieve an integrated understanding of the emergence of hippocampal function and spatial cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.