ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Space in the brain: how the hippocampal formation supports spatial cognition.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
203 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Egocentric and Allocentric Spatial Memory in Mild Cognitive Impairment with Real-World and Virtual Navigation Tasks: A Systematic Review.Journal of Alzheimer's disease : JAD · 2021Pooled it
- Personalized Virtual Reality Compared With Guided Imagery for Enhancing the Impact of Progressive Muscle Relaxation Training: Pilot Randomized Controlled Trial.JMIR mental health · 2024Trial
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- Article
- Real-space navigation in patients with focal epilepsy underpins the prominent role of the hippocampus for allocentric navigation in humans.Journal of neurology · 2026Article
- Experience-dependent emergence of multi-scale spatial organization during foraging in freely moving marmosets.iScience · 2026Article
- A Conserved Mammalian Hippocampal Navigation Motif Reconfigured for Primate Vision.bioRxiv : the preprint server for biology · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Egocentric Dominance in Spatial Representations: The Role of Environmental Familiarity in Building Cognitive Maps.Brain and behavior · 2026Article
- (Remembering) Vector Coding of Boundaries and Objects in the Subiculum.Hippocampus · 2026Review
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Quantitative reconstruction of neuronal mitochondrial network in neurites and somata in rat hippocampus and prefrontal cortex.Frontiers in physiology · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- The Map's Design: Evolution's Impact on Navigation and Spatial Cognition.Animals : an open access journal from MDPI · 2025Review
- Brain and Immune System Part II-An Integrative View upon Spatial Orientation, Learning, and Memory Function.International journal of molecular sciences · 2025Review
- The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events.bioRxiv : the preprint server for biology · 2025Article
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation.Neuron · 2025Article
143 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Over the past four decades, research has revealed that cells in the hippocampal formation provide an exquisitely detailed representation of an animal's current location and heading. These findings have provided the foundations for a growing understanding of the mechanisms of spatial cognition in mammals, including humans. We describe the key properties of the major categories of spatial cells: place cells, head direction cells, grid cells and boundary cells, each of which has a characteristic firing pattern that encodes spatial parameters relating to the animal's current position and orientation. These properties also include the theta oscillation, which appears to play a functional role in the representation and processing of spatial information. Reviewing recent work, we identify some themes of current research and introduce approaches to computational modelling that have helped to bridge the different levels of description at which these mechanisms have been investigated. These range from the level of molecular biology and genetics to the behaviour and brain activity of entire organisms. We argue that the neuroscience of spatial cognition is emerging as an exceptionally integrative field which provides an ideal test-bed for theories linking neural coding, learning, memory and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.