ArticleMolecules (Basel, Switzerland)2013
Bioactive compounds from the roots of Asiasarum heterotropoides.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comparative Biochemical and Pharmacodynamic Analyses ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia EthnomedicineFrontiers in chemistry · 2022Article
- Triterpenoid Saponin and Lignan Glycosides from the Traditional Medicine Elaeagnus angustifolia Flowers and Their Cytotoxic Activities.Molecules (Basel, Switzerland) · 2020Article
- Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53.BMC complementary and alternative medicine · 2019Article
- Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity.Molecules (Basel, Switzerland) · 2017Article
- Biological activity and photostability of biflorin micellar nanostructures.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
6 authors.
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Abstract
A new tetrahydrofuran lignan, (7S,8R,7'S,8'S)-3-methoxy-3',4'-methylenedioxy-7,9'-epoxylignane-4,7',9-triol (1), and 21 known compounds 2-22 were isolated from the roots of Asiasarum heterotropoides by chromatographic separation methods. The structures of all compounds 1-22 were elucidated by spectroscopic analysis including 1D- and 2D-NMR. Fourteen of these compounds (1-3, 7, 10, 12-17, 19, 21, and 22) were isolated from this species in this study for the first time. All of the isolates were evaluated for their anticancer activities using in vitro assays. Among the 22 tested compounds, two (compounds 5 and 7) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity.
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