ArticleHypertension (Dallas, Tex. : 1979)2014
17β-Estradiol protects against the progression of hypertension during adulthood in a mouse model of systemic lupus erythematosus.
Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- The double-edged sword effect of estrogen in kidney disease and its precision modulation.Frontiers in endocrinology · 2026Review
- Chronic Stress Induces Sex-Specific Renal Mitochondrial Dysfunction in Mice.Function (Oxford, England) · 2025Article
- Estradiol-mediated small GTP-binding protein GDP dissociation stimulator induction contributes to sex differences in resilience to ferroptosis in takotsubo syndrome.Redox biology · 2023Article
- Protective effects of long-term nitrate administration against ovariectomy-induced kidney dysfunction in rats.Pharmacological reports : PR · 2023Article
- Hypertension and endothelial dysfunction in the pristane model of systemic lupus erythematosus.Physiological reports · 2021Article
- Possible protective role of 17β-estradiol against COVID-19.Journal of allergy and infectious diseases · 2020Article
- Human recombinant relaxin-2 does not attenuate hypertension or renal injury but exacerbates vascular dysfunction in a female mouse model of SLE.American journal of physiology. Heart and circulatory physiology · 2019Article
- Mechanisms of hypertension in autoimmune rheumatic diseases.British journal of pharmacology · 2019Review
- Cyclophosphamide treatment for hypertension and renal injury in an experimental model of systemic lupus erythematosus.Physiological reports · 2019Article
- Autoimmune Disease-Associated Hypertension.Current hypertension reports · 2019Review
- Pharmacological potentiation of the efferent vagus nerve attenuates blood pressure and renal injury in a murine model of systemic lupus erythematosus.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Increased sleep time and reduced energy expenditure contribute to obesity after ovariectomy and a high fat diet.Life sciences · 2018Article
- Anti-CD3 antibody therapy attenuates the progression of hypertension in female mice with systemic lupus erythematosus.Pharmacological research · 2017Article
- Immunosuppression With Mycophenolate Mofetil Attenuates Hypertension in an Experimental Model of Autoimmune Disease.Journal of the American Heart Association · 2017Article
- Understanding mechanisms of hypertension in systemic lupus erythematosus.Therapeutic advances in cardiovascular disease · 2016Review
- Prediction of disease-gene-drug relationships following a differential network analysis.Cell death & disease · 2016Article
- Estrogen in cardiovascular disease during systemic lupus erythematosus.Clinical therapeutics · 2014Review
- Impact of early life ovariectomy on blood pressure and body composition in a female mouse model of systemic lupus erythematosus.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Preventing autoimmunity protects against the development of hypertension and renal injury.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Environmental factors, toxicants and systemic lupus erythematosus.International journal of molecular sciences · 2014Review
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3 authors at 1 institution in 1 country.
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Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder with a high prevalence of hypertension and cardiovascular disease. Because SLE predominantly affects women, estrogen is commonly implicated as a contributor to SLE disease progression. Using an established mouse model of SLE (female NZBWF1), we tested whether estrogen has a causal role in the development of hypertension in adulthood. Thirty-week-old SLE and control mice (NZW/LacJ) underwent either a sham or ovariectomy (OVX) procedure. 17β-Estradiol (E2; 5 μg/mouse, twice/week, subcutaneously) was administered to a subset of OVX mice. Mean arterial pressure (in mm Hg) was increased in SLE mice (134±4 versus 119±3 in controls). Contrary to our hypothesis, OVX exacerbated the hypertension in female SLE mice (153±3; P<0.05 versus SLE sham), and repletion of E2 prevented the OVX-induced increase in blood pressure (132±2). The prevalence of albuminuria was increased in SLE mice compared with controls (37% versus 0%). OVX increased the prevalence in SLE mice (70% versus 37% in SLE shams). Repletion of E2 completely prevented albuminuria in OVX SLE mice. Renal cortical tumor necrosis factor α was increased in SLE mice compared with controls and was further increased in OVX SLE. The OVX-induced increase in renal tumor necrosis factor α expression was prevented by repletion of E2. Treatment of OVX SLE mice with the tumor necrosis factor α inhibitor, etanercept, blunted the OVX-induced increase in blood pressure (140±2) and prevalence of albuminuria (22%). These data suggest that 17β-estradiol protects against the progression of hypertension during adulthood in SLE, in part, by reducing tumor necrosis factor α.
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